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020 _a9781592596515
_9978-1-59259-651-5
024 7 _a10.1385/1592596517
_2doi
050 4 _aRM300-666
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
072 7 _aMKG
_2thema
082 0 4 _a615
_223
245 1 0 _aIn Vitro Neurotoxicology
_h[electronic resource] :
_bPrinciples and Challenges /
_cedited by Evelyn Tiffany-Castiglioni.
250 _a1st ed. 2004.
264 1 _aTotowa, NJ :
_bHumana Press :
_bImprint: Humana,
_c2004.
300 _aXV, 331 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Pharmacology and Toxicology,
_x1940-6053
505 0 _aIn Vitro Neurotoxicology -- Predictive Value of In Vitro Systems for Neurotoxicity Risk Assessment -- Exposure-Dose-Response Paradigm as It Relates to Toxicogenomics -- In Vitro Studies of Neurotoxicant Effects on Cellular Homeostasis -- Role of Apoptosis in Neurotoxicology -- Impairment of Neurotransmitter Metabolism and Function by Neurotoxicants -- Cell-Type Specific Responses of the Nervous System to Lead -- Effects of Toxicants on Neural Differentiation -- Impairment of Synaptic Function by Exposure to Lead -- Aggregating Brain Cell Cultures for Neurotoxicological Studies -- Use of Complimentary In Vitro and In Vivo Methods for Assessing Neuroendocrine Disruptors -- Establishing In Vitro Models to Study Endogenous Neurotoxicants.
520 _aNeurotoxicity assessment with in vitro systems offers not only a means to better understand mechanisms of action of toxicants and decrease reliance on laboratory animals, but also provides a basis for reliable, high throughput screening of new and untested chemicals. In In Vitro Neurotoxicology: Principles and Challenges, well-respected leaders in the field take a fresh look at their own and others' work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. In thematically organized chapters, the authors employ examples comprised of multiple experimental systems and endpoints, and discuss the use of complementary in vivo/in vitro strategies. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well studied both in vivo and in vitro: lead, mercury, organophosphorus insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. Several neurotoxicology topics covered provide insight into neurodevelopmental and neurodegenerative diseases, including the concept of astroglia as depots for lead and other metals in the central nervous system, the elucidation of factors involved in the onset of puberty in females, and the exploration of endogenous proteins as neurotoxicants. Authoritative and forward-looking, In Vitro Neurotoxicology: Principles and Challenges sets out new concepts and research directions that will facilitate significant improvement in today's methods and systems for in vitro neurotoxicity testing.
650 0 _aPharmacology.
650 1 4 _aPharmacology.
700 1 _aTiffany-Castiglioni, Evelyn.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781588290472
776 0 8 _iPrinted edition:
_z9781617373237
776 0 8 _iPrinted edition:
_z9781489939647
830 0 _aMethods in Pharmacology and Toxicology,
_x1940-6053
856 4 0 _uhttps://doi.org/10.1385/1592596517
912 _aZDB-2-PRO
999 _c8587
_d8587