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| 001 | 978-1-0716-5218-3 | ||
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| 005 | 20260610083723.0 | ||
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| 008 | 260401s2026 xxu| s |||| 0|eng d | ||
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_a9781071652183 _9978-1-0716-5218-3 |
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_a10.1007/978-1-0716-5218-3 _2doi |
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| 050 | 4 | _aRC268.4-.44 | |
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_aPSAK _2bicssc |
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_aMJCL _2bicssc |
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_aPSAK _2thema |
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_aMJCL _2thema |
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_aADAMTS Proteases _h[electronic resource] : _bMethods and Protocols / _cedited by X. Long Zheng. |
| 250 | _a1st ed. 2026. | ||
| 264 | 1 |
_aNew York, NY : _bSpringer US : _bImprint: Humana, _c2026. |
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_aXI, 309 p. 55 illus., 47 illus. in color. _bonline resource. |
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_acomputer _bc _2rdamedia |
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_aonline resource _bcr _2rdacarrier |
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_bPDF/UA-1 _2onix |
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_bTable of contents navigation _2onix |
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_bSingle logical reading order _2onix |
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_bShort alternative textual descriptions _2onix |
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_bUse of color is not sole means of conveying information _2onix |
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_bUse of high contrast between text and background color _2onix |
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_bAll non-decorative content supports reading without sight _2onix |
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_atext file _bPDF _2rda |
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_aMethods in Molecular Biology, _x1940-6029 ; _v3027 |
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| 505 | 0 | _aAn overview of ADAMTS proteases -- Overview of the Roles of ADAMTS1 in Ovarian Biology -- Methods for Defining the Role of ADAMTS1 in the Ovary -- Modeling Aspects of Human Placental Development with Trophoblast Stem Cells -- Exploring The Role of ADAMTS4 Expression in Atherosclerosis -- Method for Generation of adamtsl4 knock-out zebrafish lines using CRRISPR/Cas9 system -- Assay for neurocan-degrading activity of ADAMTS12 metalloprotease -- Generating adamts13-/- Zebrafish via CRISPR/Cas9 Gene Editing -- Determining ADAMTS13 conformation for the diagnosis of immune thrombotic thrombocytopenic purpura and prediction of relapse -- Methods for studying the role of ADAMTS13 in angiogenesis -- Assays for Plasma ADAMTS13 Activity and Inhibitors using recombinant FRETS-VWF73 peptide -- A Vortex-Shear Based Assay for Cleavage of Multimeric VWF by ADAMTS13 -- Deep protease profiling to define the substrate specificity of ADAMTS proteases -- Microfluidic shear-based assay for assessing ADAMTS13 activity under flow- Optical‑Tweezers Single‑Molecule Assay for ADAMTS13‑Mediated Proteolysis of the von Willebrand Factor A2 Domain -- Method for Assessing Inhibition Kinetics of Autoantibodies Against ADAMTS13 in Immune Thrombotic Thrombocytopenic Purpura -- Hydrogen Exchange Mass Spectrometry for Mapping Antibody Binding Sites and Conformational Dynamics of ADAMTS13 -- Treating Immune Thrombotic Thrombocytopenic Purpura with Therapeutic Plasma Exchange -- Molecular Dynamics Simulations with NAMD and Trajectory Analysis -- Treating immune-mediated thrombotic thrombocytopenic purpura by Caplacizumab -- Treating Immune Thrombocytopenic Purpura by Immunosuppressive Agents. | |
| 520 | _aThis volume provides methods for the analysis of ADAMTS proteases and ADAMTS-like proteins. Chapters detail ADAMTS family members, with special attention to the exciting progress made in understanding ADAMTS13—its biology, disease mechanisms, detection, and clinical management of a potentially fatal thrombotic microangiopathy, thrombotic thrombocytopenic purpura (TTP). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, ADAMTS Proteases: Methods and Protocol is a valuable resource for any researcher hoping to contribute to the ever expanding world of ADAMTS. | ||
| 532 | 8 | _aAccessibility summary: This PDF has been created in accordance with the PDF/UA-1 standard to enhance accessibility, including screen reader support, described non-text content (images, graphs), bookmarks for easy navigation, keyboard-friendly links and forms and searchable, selectable text. We recognize the importance of accessibility, and we welcome queries about accessibility for any of our products. If you have a question or an access need, please get in touch with us at accessibilitysupport@springernature.com. Please note that a more accessible version of this eBook is available as ePub. | |
| 532 | 8 | _aNo reading system accessibility options actively disabled | |
| 532 | 8 | _aPublisher contact for further accessibility information: accessibilitysupport@springernature.com | |
| 650 | 0 |
_aCancer _xGenetic aspects. |
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| 650 | 1 | 4 | _aCancer Genetics and Genomics. |
| 700 | 1 |
_aZheng, X. Long. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt |
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| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer Nature eBook | |
| 776 | 0 | 8 |
_iPrinted edition: _z9781071652176 |
| 776 | 0 | 8 |
_iPrinted edition: _z9781071652190 |
| 776 | 0 | 8 |
_iPrinted edition: _z9781071652206 |
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_aMethods in Molecular Biology, _x1940-6029 ; _v3027 |
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| 856 | 4 | 0 | _uhttps://doi.org/10.1007/978-1-0716-5218-3 |
| 912 | _aZDB-2-PRO | ||
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_c8571 _d8571 |
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