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020 _a9781493909568
_9978-1-4939-0956-8
024 7 _a10.1007/978-1-4939-0956-8
_2doi
050 4 _aRM300-666
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
072 7 _aMKG
_2thema
082 0 4 _a615
_223
245 1 0 _aPharmacogenomics in Drug Discovery and Development
_h[electronic resource] /
_cedited by Qing Yan.
250 _a2nd ed. 2014.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Humana,
_c2014.
300 _aXIII, 715 p. 44 illus., 32 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Molecular Biology,
_x1940-6029 ;
_v1175
505 0 _aFrom Pharmacogenomics and Systems Biology to Personalized Care: A Framework of Systems and Dynamical Medicine -- Translational Bioinformatics Approaches for Systems and Dynamical Medicine -- Whole Blood Transcriptomic Analysis to Identify Clinical Biomarkers of Drug Response -- Diagnostic Procedures for Paraffin Embedded Tissues Analysis in Pharmacogenomic Studies -- Approach to Clinical and Genetic Characterization of Statin-Induced Myopathy -- Pharmacogenetics of Membrane Transporters: A Review of Current Approaches -- G Protein-Coupled Receptor Accessory Proteins and Signaling: Pharmacogenomic Insights -- G Protein-Coupled Receptor Mutations and Human Genetic Disease -- Pharmacogenetics of the G Protein-Coupled Receptors -- Pharmacogenomics of Heart Failure -- Pharmacogenomics in the Development and Characterization of Atheroprotective Drugs -- Management of Side-Effects in the Personalized Medicine Era: Chemotherapy Induced Peripheral Neuropathy -- Pharmacogenomics of Alzheimer’s Disease: Novel Therapeutic Strategies for Drug Development -- Pharmacogenetics of Antipsychotic Treatment in Schizophrenia -- Pharmacogenetics of Addiction Therapy -- Pharmacogenetics in Rheumatoid Arthritis -- The Pharmacogenomics of Osteoporotic Fractures -- Pharmacogenomics and Pharmacoepigenomics in Pediatric Medicine -- Pharmacogenomics in Children.
520 _aCovering topics from individual molecules to systemic diseases, from basic concepts to advanced technologies, Pharmacogenomics in Drug Discovery and Development , Second Edition provides a practical, state-of-the-art and integrative view of the application of pharmacogenomics in drug discovery and development. A wide range of theoretical and experimental approaches are introduced to meet the problem-solving objectives for understanding the complexity in health and diseases, from laboratory tests to computational analysis. The development of pharmacogenomics represents the evolution of biomedicine from treating the disease itself to treating the malfunction of an individual person, the “root” of diseases. With the change of focus from disease-centered to human-centric medicine, pharmacogenomics brings hope for the transformation from simple disease treatment to accurate prediction and effective prevention. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.   Authoritative and easily accessible, Pharmacogenomics in Drug Discovery and Development, Second Edition seeks to serve both professionals and novices with comprehensive resources and a holistic view for the translation of pharmacogenomics into better preventive and personalized medical care.
650 0 _aPharmacology.
650 1 4 _aPharmacology.
700 1 _aYan, Qing.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781493909551
776 0 8 _iPrinted edition:
_z9781493909575
776 0 8 _iPrinted edition:
_z9781493947584
830 0 _aMethods in Molecular Biology,
_x1940-6029 ;
_v1175
856 4 0 _uhttps://doi.org/10.1007/978-1-4939-0956-8
912 _aZDB-2-PRO
999 _c8553
_d8553