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020 _a9781493937981
_9978-1-4939-3798-1
024 7 _a10.1007/978-1-4939-3798-1
_2doi
050 4 _aRM300-666
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
072 7 _aMKG
_2thema
082 0 4 _a615
_223
245 1 0 _aG Protein-Coupled Receptor Kinases
_h[electronic resource] /
_cedited by Vsevolod V. Gurevich, Eugenia V. Gurevich, John J.G. Tesmer.
250 _a1st ed. 2016.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Humana,
_c2016.
300 _aXI, 329 p. 36 illus., 33 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Pharmacology and Toxicology,
_x1940-6053
505 0 _aG Protein-Coupled Receptor Kinases (GRKs) History: Evolution and Discovery -- Structure and Function of G Protein-Coupled Receptor Kinases 1 and 7 -- Visual G Protein-Coupled Receptor Kinases -- Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily -- “Barcode” and Differential Effects of GPCR Phosphorylation by Different GRKs -- Cell-Type Specific GRK2 Interactomes: Physiopathological Implications -- Differential Regulation of IGF-1 and Insulin Signaling by GRKs -- Differential Control of Potassium Channel Activity by GRK2 -- Critical Role of GRK2 in the Prevention of Chronic Pain -- Roles of GRK Dysfunction in Alzheimer’s Pathogenesis -- Regulation of Dopamine-Dependent Behaviors by G Protein-Coupled Receptor Kinases -- G Protein-Coupled Receptors and Their Kinases in Cardiac Regulation -- GRK Roles in C. elegans -- Evolutionarily Conserved Role of G Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathway.
520 _aThis collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs. Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.
650 0 _aPharmacology.
650 1 4 _aPharmacology.
700 1 _aGurevich, Vsevolod V.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aGurevich, Eugenia V.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aTesmer, John J.G.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781493937967
776 0 8 _iPrinted edition:
_z9781493937974
776 0 8 _iPrinted edition:
_z9781493981427
830 0 _aMethods in Pharmacology and Toxicology,
_x1940-6053
856 4 0 _uhttps://doi.org/10.1007/978-1-4939-3798-1
912 _aZDB-2-PRO
999 _c8532
_d8532