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020 _a9781071637869
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024 7 _a10.1007/978-1-0716-3786-9
_2doi
050 4 _aRM300-666
072 7 _aMMG
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072 7 _aMED071000
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072 7 _aMKG
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082 0 4 _a615
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245 1 0 _aCharacterization of Nanoparticles Intended for Drug Delivery
_h[electronic resource] /
_cedited by Jeffrey D. Clogston, Rachael M. Crist, Marina A. Dobrovolskaia, Stephan T. Stern.
250 _a3rd ed. 2024.
264 1 _aNew York, NY :
_bSpringer US :
_bImprint: Humana,
_c2024.
300 _aXII, 324 p. 1 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
341 0 _bTable of contents navigation
_2onix
341 0 _bSingle logical reading order
_2onix
341 0 _bShort alternative textual descriptions
_2onix
341 0 _bUse of color is not sole means of conveying information
_2onix
341 0 _bUse of high contrast between text and background color
_2onix
341 0 _bNext / Previous structural navigation
_2onix
341 0 _bAll non-decorative content supports reading without sight
_2onix
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Molecular Biology,
_x1940-6029 ;
_v2789
505 0 _aAdvancements in Nanoparticle Characterization -- Nanoparticle Size Distribution and Stability Assessment Using Asymmetric-Flow Field-Flow Fractionation -- Assessment of Protein Binding Using Asymmetric-Flow Field-Flow Fractionation Combined with Multi-Angle Light Scattering and Dynamic Light Scattering -- Quantitation of Active Pharmaceutical Ingredients in Polymeric Drug Products Using Elemental Analysis -- Particle Size and Concentration Measurement Using the Spectradyne nCS1 Instrument -- Measuring Size and Number Concentration of Metallic Nanoparticles Using spICP-MS -- Ion Quantitation in Liposomal Products with RP-HPLC and Charged Aerosol Detection -- A Static Headspace Gas Chromatography Method for Quantitation of Residual Solvents in Nanoformulations -- Current Considerations and Practical Solutions for Overcoming Nanoparticle Interference with LAL Assays and Minimizing Endotoxin Contamination -- Detection of Beta-Glucan Contamination inNanoparticle Formulations -- Detection of Intracellular Complement Activation by Nanoparticles in Human T Lymphocytes -- Analysis of Nanoparticles’ Potential to Induce Autoimmunity -- Analysis of Nanoparticles’ Effects on Drug-Induced Psoriasis -- Detection of Nanoparticle-Mediated Total Oxidative Stress in T-Cells Using CM-H2DCFDA Dye -- Detection of Induction of Mitochondrial Oxidative Stress by Nanoparticles in T-Cells Using MitoSOX Red Dye -- Detection of Nanoparticle-Mediated Change in Mitochondrial Membrane Potential in T-Cells Using JC-1 Dye -- Detection of Antigen Presentation by Murine Bone Marrow-Derived Dendritic Cells After Treatment with Nanoparticles -- Antigen-Specific Stimulation of CD8+ T-Cells by Murine Bone Marrow-Derived Dendritic Cells After Treatment with Nanoparticles -- Detection of Pre-Existing Antibodies to Polyethylene Glycol and PEGylated Liposomes in Human Serum -- In Vitro and In Vivo Methods for Analysis of Nanoparticle Potential to Induce Delayed-Type Hypersensitivity Reactions -- Analysis of Nanoparticle Adjuvant Properties -- Methods for Analysis of Nanoparticle Immunosuppressive Properties -- Evaluation of the Acute Anaphylactoid Reactogenicity of Nanoparticle-Containing Medicines and Vaccines Using the Porcine CARPA Model -- Immunophenotyping, Part I: Instrument Calibration and Reagent Qualification for immunophenotyping Analysis of Human Peripheral Blood Mononuclear Cell Cultures -- Immunophenotyping, Part II: Analysis of Nanoparticle Effects on the Composition and Activation Status of Human Peripheral Blood Mononuclear Cells -- Understanding the Role of Scavenger Receptor A1 in Nanoparticle Uptake by Murine Macrophages -- Assessment of Temperature-Dependent Drug Release of Solubilizing Nanoformulations Using the SITUA -- Evaluation of Nanomedicine Tissue Distribution and Stability by Alexa Fluor 488 and PEG Immunohistochemistry.
520 _aThis third edition volume expands on the previous editions with new and updated discussions on the latest developments in endotoxin contamination, complex physicochemical properties, in vitro immunotoxicity traits, and in vitro drug release properties. Eight chapters in this book are dedicated to physicochemical characterization techniques and cover newer methods such as asymmetric-flow field-flow fractionation, single particle inductively coupled plasma mass spectrometry, and resistive pulse sensing. The next eighteen chapters explore the immunotoxicity of nanomaterials, including microbial contaminants such as endotoxin and beta-glucans, anti-PEG antibodies, autoimmunity, and immunosuppressive properties. The last two chapters talk about new pharmacology protocols, including a new technique to assess drug release and a tissue distribution assay using PEG immunohistochemistry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step instructions to reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Characterization of Nanoparticles Intended for Drug Delivery, Third Edition is a valuable resource that will help both expert and novice researchers further enhance their understanding of this important and developing field.
532 8 _aAccessibility summary: This PDF does not fully comply with PDF/UA standards, but does feature limited screen reader support, described non-text content (images, graphs), bookmarks for easy navigation and searchable, selectable text. Users of assistive technologies may experience difficulty navigating or interpreting content in this document. We recognize the importance of accessibility, and we welcome queries about accessibility for any of our products. If you have a question or an access need, please get in touch with us at accessibilitysupport@springernature.com.
532 8 _aNo reading system accessibility options actively disabled
532 8 _aPublisher contact for further accessibility information: accessibilitysupport@springernature.com
650 0 _aPharmacology.
650 0 _aNanotechnology.
650 0 _aToxicology.
650 1 4 _aPharmacology.
650 2 4 _aNanotechnology.
650 2 4 _aToxicology.
700 1 _aClogston, Jeffrey D.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aCrist, Rachael M.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aDobrovolskaia, Marina A.
_eeditor.
_0(orcid)0000-0002-4233-9227
_1https://orcid.org/0000-0002-4233-9227
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aStern, Stephan T.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781071637852
776 0 8 _iPrinted edition:
_z9781071637876
776 0 8 _iPrinted edition:
_z9781071637883
830 0 _aMethods in Molecular Biology,
_x1940-6029 ;
_v2789
856 4 0 _uhttps://doi.org/10.1007/978-1-0716-3786-9
912 _aZDB-2-PRO
999 _c8281
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