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001 978-1-61779-618-0
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020 _a9781617796180
_9978-1-61779-618-0
024 7 _a10.1007/978-1-61779-618-0
_2doi
050 4 _aRM300-666
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
072 7 _aMKG
_2thema
082 0 4 _a615
_223
245 1 4 _aThe Handbook of Metabolomics
_h[electronic resource] /
_cedited by Teresa Whei-Mei Fan, Andrew N. Lane, Richard M. Higashi.
250 _a1st ed. 2012.
264 1 _aTotowa, NJ :
_bHumana Press :
_bImprint: Humana,
_c2012.
300 _aX, 484 p. 140 illus., 43 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Pharmacology and Toxicology,
_x1940-6053
505 0 _aIntroduction to Metabolomics -- Considerations of Sample Preparation for Metabolomics Investigation -- Clinical Aspects of Metabolomics -- Structural Mass Spectrometry for Metabolomics -- Metabolomic Applications of Inductively Coupled Plasma- Mass Spectrometry (ICP-MS) -- Principles of NMR for Applications in Metabolomics -- Novel NMR and MS Approaches to Metabolomics -- Metabolic Flux Analysis -- Introduction to Metabolic Control Analysis (MCA) -- Application of Tracer-Based Metabolomics and Flux Analysis in Targeted Cancer Drug Design -- Non-Invasive Fluxomics in Mammals by Nuclear Magnetic Resonance Spectroscopy -- Compositional Analysis of Phospholipids by Mass Spectrometry and Phosphorus-31 Nuclear Magnetic Resonance Spectroscopy -- The HumanCyc Pathway-Genome Database and Pathway Tools Software as Tools for Imaging and Analyzing Metabolomics Data -- Metabolomics-Edited Transcriptomics Analysis (META).
520 _aVital to academic researchers, the medical field, and especially to biotech and pharmaceutical scientists, metabolomics is a rapidly expanding field that will provide a key link between functional biology (phenotypes) and the inner workings of cells in tissues or whole organisms.  In The Handbook of Metabolomics, expert researchers provide readers with the current state of metabolomic development and the integration of metabolomics with transcriptomics and proteomics, illustrated by research efforts related to toxicology and pharmacology. The detailed contributions deal with topics ranging from sample preparation and considerations, both laboratory and clinical, analytical methodologies for metabolite and isotopomer profiling, metabolic flux modeling, database construction, and the integration of ‘omics for systems biochemical understanding, amongst other topics.   Thorough and authoritative, The Handbook of Metabolomics serves as an ideal reference for all those who wish to further pursue this promising area of study.
650 0 _aPharmacology.
650 1 4 _aPharmacology.
700 1 _aFan, Teresa Whei-Mei.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aLane, Andrew N.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aHigashi, Richard M.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781617796173
776 0 8 _iPrinted edition:
_z9781617796197
776 0 8 _iPrinted edition:
_z9781493960439
830 0 _aMethods in Pharmacology and Toxicology,
_x1940-6053
856 4 0 _uhttps://doi.org/10.1007/978-1-61779-618-0
912 _aZDB-2-PRO
999 _c8144
_d8144