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020 _a9781493905218
_9978-1-4939-0521-8
024 7 _a10.1007/978-1-4939-0521-8
_2doi
050 4 _aRM300-666
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
072 7 _aMKG
_2thema
082 0 4 _a615
_223
245 1 0 _aIn Vitro Toxicology Systems
_h[electronic resource] /
_cedited by Anna Bal-Price, Paul Jennings.
250 _a1st ed. 2014.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Humana,
_c2014.
300 _aXXI, 583 p. 64 illus., 54 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Pharmacology and Toxicology,
_x1940-6053
505 0 _aThe Past, Present and Future of Chemical Risk Assessment.- In Vitro Systems for Hepatotoxicity Testing -- In Vitro Methods for Cardiotoxicity Testing -- Renal Cell Culture -- Cellular Models for In Vitro Lung Toxicology -- In Vitro Developmental Neurotoxicity Testing: Relevant Models and Endpoints -- Blood Brain Barrier In Vitro Models and Their Applications in Toxicology -- Ocular Toxicity -- In Vitro Models for Ototoxic Research -- Dermal Toxicity: Skin Sensitization -- Immunotoxicity -- Reproductive Toxicity -- Evaluating Endocrine Disruption In Vitro -- Current and Emerging In Vitro Methods for Genotoxicity and Carcinogenicity -- Use of Induced Pluripotent Stem Cells in Drug Toxicity Screening -- Human Stem/Progenitor Cell-Based Assays for Neurodevelopmental Toxicity Testing -- High Content Imaging Approaches for In Vitro Toxicology -- Application of Omics Technologies to In Vitro Toxicology -- Stress Response Pathways -- Translational Biomarkers, In Vitro and In Vivo -- Nanotoxicology -- Consideration of Metabolism in In Vitro Cellular Systems -- In Vitro Approaches to Predictive Biokinetics -- Extrapolating In Vitro Results to Predict Human Toxicity -- Considerations in the Development of In Vitro Toxicity Testing Methods Intended for Regulatory Use.
520 _aIn Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches. Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists, and regulators working in the field of chemical safety assessment but also to a wider scientific audience.
650 0 _aPharmacology.
650 0 _aMedicine
_xResearch.
650 0 _aBiology
_xResearch.
650 1 4 _aPharmacology.
650 2 4 _aBiomedical Research.
700 1 _aBal-Price, Anna.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aJennings, Paul.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781493905201
776 0 8 _iPrinted edition:
_z9781493905225
776 0 8 _iPrinted edition:
_z9781493954803
830 0 _aMethods in Pharmacology and Toxicology,
_x1940-6053
856 4 0 _uhttps://doi.org/10.1007/978-1-4939-0521-8
912 _aZDB-2-PRO
999 _c8119
_d8119