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001 978-1-62703-392-3
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020 _a9781627033923
_9978-1-62703-392-3
024 7 _a10.1007/978-1-62703-392-3
_2doi
050 4 _aQD431-431.7
072 7 _aPSBC
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aPSB
_2thema
082 0 4 _a572.6
_223
245 1 0 _aMass Spectrometry Data Analysis in Proteomics
_h[electronic resource] /
_cedited by Rune Matthiesen.
250 _a2nd ed. 2013.
264 1 _aTotowa, NJ :
_bHumana Press :
_bImprint: Humana,
_c2013.
300 _aX, 405 p. 93 illus., 59 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Molecular Biology,
_x1940-6029 ;
_v1007
505 0 _aIntroduction to Mass Spectrometry-Based Proteomics -- LC-MS Spectra Processing -- Isotopic Distributions -- Retention Time Prediction and Protein Identification -- Algorithms for Database Dependent Search of MSMS Data -- Interpretation of Tandem Mass Spectra of Post-Translationally Modified Peptides -- Improving Peptide Identification Using Empirical Scoring Systems -- Methods and Algorithms for Quantitative Proteomics by Mass Spectrometry -- Computational Approaches to Selected Reaction Monitoring (SRM) Assay Design -- Feature Selection and Machine Learning with Mass Spectrometry Data -- Considerations in the Analysis of Hydrogen Exchange Mass Spectrometry Data -- Permethylated N-Glycan Analysis with Mass Spectrometry -- Mass Spectrometry Methods for Studying Glycosylation in Cancer -- Proteomics Data Exchange and Storage: The Need for Common Standards and Public Repositories -- Tools for Protein Post Translational Modifications Analysis: FAK, A Case Study -- Proteomic Strategies to Characterize Signaling Pathways -- Simple Proteomics Data Analysis in the Object-Oriented PowerShell.
520 _aSince the publishing of the first edition, the methodologies and instrumentation involved in the field of mass spectrometry-based proteomics has improved considerably.  Fully revised and expanded, Mass Spectrometry Data Analysis in Proteomics, Second Edition presents expert chapters on specific MS-based methods or data analysis strategies in proteomics. The volume covers data analysis topics relevant for quantitative proteomics, post translational modification, HX-MS, glycomics, and data exchange standards, among other topics.  Written in the highly successful Methods in Molecular Biology series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.   Updated and authoritative, Mass Spectrometry Data Analysis in Proteomics, Second Edition serves as a detailed guide for all researchers seeking to further our knowledge in the field of proteomics.
650 0 _aProteins .
650 0 _aMass spectroscopy.
650 1 4 _aProtein Biochemistry.
650 2 4 _aMass Spectrometry.
700 1 _aMatthiesen, Rune.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781627033916
776 0 8 _iPrinted edition:
_z9781627033930
776 0 8 _iPrinted edition:
_z9781493959952
830 0 _aMethods in Molecular Biology,
_x1940-6029 ;
_v1007
856 4 0 _uhttps://doi.org/10.1007/978-1-62703-392-3
912 _aZDB-2-PRO
999 _c7743
_d7743