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020 _a9781493963553
_9978-1-4939-6355-3
024 7 _a10.1007/978-1-4939-6355-3
_2doi
050 4 _aRM300-666
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
072 7 _aMKG
_2thema
082 0 4 _a615
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245 1 0 _aAntiepileptic Drug Discovery
_h[electronic resource] :
_bNovel Approaches /
_cedited by Alan Talevi, Luisa Rocha.
250 _a1st ed. 2016.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Humana,
_c2016.
300 _aXI, 386 p. 51 illus., 42 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Pharmacology and Toxicology,
_x1940-6053
505 0 _aInflammatory Cytokines as Targets for Epilepsy Drug Therapy -- The Use of Anti-Inflammatory Drugs in Epilepsy -- Carbonic Anhydrase and Epilepsy -- Synaptic Vesicle Protein 2A as a Novel Pharmacological Target with Broad Potential for New Antiepileptic Drugs -- Do Cannabinoids Represent a Good Therapeutic Strategy for Epilepsy? -- Glutamate Receptors as Targets for Novel Antiepileptic Drug Therapy -- Neurosteroid Regulation of Seizures: Role of GABAA Receptor Plasticity -- Erythropoietin as Potential Neuroprotective and Antiepileptogenic Agent in Epilepsy and Refractory Epilepsy -- Caloric Restriction and Dietary Treatments of Epilepsy: Mechanistic Insights for Drug Discovery -- Gene Therapy in Epilepsy -- Human Brain Tissue as a Model for the Study of Epilepsy -- The Blood-Brain Barrier and the Design of New Antiepileptic Drugs -- Virtual Screening Applications in the Search of Novel Antiepileptic Drug Candidates -- Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Ligand-Based Approximations -- Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Structure-Based Approximations -- Nanoformulations of Antiepileptic Drugs: In Vitro and In Vivo Studies -- Side Effects of Antiepileptic Drugs -- Network Pharmacology and Epilepsy -- The Importance of Drug Repurposing in the Field of Antiepileptic Drug Development.
520 _aThis thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory. Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and thediscovery of new antiepileptic drugs.
650 0 _aPharmacology.
650 1 4 _aPharmacology.
700 1 _aTalevi, Alan.
_eeditor.
_0(orcid)0000-0003-3178-826X
_1https://orcid.org/0000-0003-3178-826X
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aRocha, Luisa.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781493963539
776 0 8 _iPrinted edition:
_z9781493963546
776 0 8 _iPrinted edition:
_z9781493981748
830 0 _aMethods in Pharmacology and Toxicology,
_x1940-6053
856 4 0 _uhttps://doi.org/10.1007/978-1-4939-6355-3
912 _aZDB-2-PRO
999 _c7687
_d7687