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008 170817s2017 xxu| s |||| 0|eng d
020 _a9781493972081
_9978-1-4939-7208-1
024 7 _a10.1007/978-1-4939-7208-1
_2doi
050 4 _aRM300-666
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
072 7 _aMKG
_2thema
082 0 4 _a615
_223
245 1 0 _aDevelopmental and Reproductive Toxicology
_h[electronic resource] /
_cedited by Ali S. Faqi.
250 _a1st ed. 2017.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Humana,
_c2017.
300 _aXII, 314 p. 24 illus., 17 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Pharmacology and Toxicology,
_x1940-6053
505 0 _aMetabolism and Drug-Drug Interaction in Pregnant Mother/Placenta/Fetus -- Critical Periods of Development in Teratology -- Nonclinical Safety Assessment of Developmental and Reproductive Toxicology: Considerations for Conducting Fertility, Embryo-Fetal Development, and Pre- and Postnatal Developmental Toxicology Studies -- A Developmental and Reproductive Toxicology Program for Chemical Registration -- The Influence of Environmental Contaminants and Lifestyle on Testicular Damage and Male Fertility -- Effects of Chemicals on Mammary Gland Development -- Alternative Methods Used to Assess Potential Embryo-Fetal Developmental Risk of Pharmaceuticals -- Using the Alternative Model C. elegans in Reproductive and Developmental Toxicology Studies -- High-Throughput Screens for Embryonic Stem Cells: Stress-Forced Potency-Stemness Loss Enables Toxicological Assays.
520 _aThis meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab.  Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resourc e for researchers working in this vital field of study.
650 0 _aPharmacology.
650 1 4 _aPharmacology.
700 1 _aFaqi, Ali S.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781493972067
776 0 8 _iPrinted edition:
_z9781493972074
776 0 8 _iPrinted edition:
_z9781493984169
830 0 _aMethods in Pharmacology and Toxicology,
_x1940-6053
856 4 0 _uhttps://doi.org/10.1007/978-1-4939-7208-1
912 _aZDB-2-PRO
999 _c7081
_d7081