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020 _a9781603272636
_9978-1-60327-263-6
024 7 _a10.1007/978-1-60327-263-6
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aSCI089000
_2bisacsh
072 7 _aPSAN
_2thema
082 0 4 _a612.8
_223
245 1 0 _aAnimal Models of Epilepsy
_h[electronic resource] :
_bMethods and Innovations /
_cedited by Scott C. Baraban.
250 _a1st ed. 2009.
264 1 _aTotowa, NJ :
_bHumana Press :
_bImprint: Humana,
_c2009.
300 _aXIII, 276 p. 58 illus., 19 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aNeuromethods,
_x1940-6045 ;
_v40
505 0 _aThe Nematode, Caenorhabditis elegans, as an Emerging Model for Investigating Epilepsy -- The Genetics and Molecular Biology of Seizure Susceptibility in Drosophila -- The Albino Xenopus laevis Tadpole as a Novel Model of Developmental Seizures -- Zebrafish as a Simple Vertebrate Organism for Epilepsy Research -- Modeling Tuberous Sclerosis Complex: Brain Development and Hyperexcitability -- BK Potassium Channel Mutations Affecting Neuronal Function and Epilepsy -- Mouse Models of Benign Familial Neonatal Convulsions (BFNC): Mutations in KCNQ (Kv7) Genes -- Interneuron Loss as a Cause of Seizures: Lessons from Interneuron-Deficient Mice -- Imaging Seizure Propagation In Vitro -- Complexity Untangled: Large-Scale Realistic Computational Models in Epilepsy -- Organotypic Hippocampal Slice Cultures as a Model of Limbic Epileptogenesis -- Seizure Analysis and Detection In Vivo -- Viral Vector Gene Therapy for Epilepsy -- Neural Stem Cells in Experimental Mesial Temporal Lobe Epilepsy.
520 _aWith its complex anatomical, molecular, electrophysiological and behavioral components, epilepsy provides the neuroscientist with nearly boundless opportunities to examine basic neurobiological mechanisms. In Animal Models of Epilepsy: Methods and Innovations, prominent investigators in the field examine several novel models of epilepsy in mice as well as in genetically tractable "simple" species such as Drosophila melanogaster (fruit flies), Caenorhabditis elegans (worms), Xenopus laevis (tadpoles) and Danio rerio (zebrafish). While covering some traditional models, the volume also explores the newest innovations like modeling seizure activity in silica and advanced strategies for seizure detection and gene therapy. As a volume in the successful Neuromethods™ series, the chapters provide clear, step-by-step protocols and thought-provoking reviews of the most recent advancements in the field. Comprehensive and cutting-edge, Animal Models of Epilepsy: Methods and Innovations is an ideal guide for scientists who wish to expand our understanding of the pathogenesis of this neurological disorder.
650 0 _aNeurosciences.
650 0 _aNeurology .
650 0 _aBiology
_xTechnique.
650 1 4 _aNeuroscience.
650 2 4 _aNeurology.
650 2 4 _aExperimental Organisms.
700 1 _aBaraban, Scott C.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781603272629
776 0 8 _iPrinted edition:
_z9781607611257
776 0 8 _iPrinted edition:
_z9781493961146
830 0 _aNeuromethods,
_x1940-6045 ;
_v40
856 4 0 _uhttps://doi.org/10.1007/978-1-60327-263-6
912 _aZDB-2-PRO
999 _c6813
_d6813