| 000 | 04948nam a22005295i 4500 | ||
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| 001 | 978-1-59259-615-7 | ||
| 003 | DE-He213 | ||
| 005 | 20260610083651.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 100301s1988 xxu| s |||| 0|eng d | ||
| 020 |
_a9781592596157 _9978-1-59259-615-7 |
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| 024 | 7 |
_a10.1385/0896031217 _2doi |
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| 050 | 4 | _aRC321-580 | |
| 072 | 7 |
_aPSAN _2bicssc |
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_aSCI089000 _2bisacsh |
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| 072 | 7 |
_aPSAN _2thema |
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_a612.8 _223 |
| 245 | 1 | 0 |
_aAnalysis of Psychiatric Drugs _h[electronic resource] / _cedited by Alan A. Boulton, Glen B. Baker, Ronald T. Coutts. |
| 250 | _a1st ed. 1988. | ||
| 264 | 1 |
_aTotowa, NJ : _bHumana Press : _bImprint: Humana, _c1988. |
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| 300 |
_aXX, 547 p. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 |
_aNeuromethods, _x1940-6045 ; _v10 |
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| 505 | 0 | _aProtein Binding of Psychotropic Drugs -- Isotope Derivative Assays for Psychotropic Drugs -- Gas—Liquid Chromatography of Antidepressant, Antipsychotic, and Benzodiazepine Drugs in Plasma and Tissues -- Gas Chromatographic— Mass Spectrometric Analysis of Antidepressants, Neuroleptics, and Benzodiazepines -- High-Performance Liquid Chromatographic Analysis of Antidepressants, Neuroleptics, and Benzodiazepines -- Principles of Radioreceptor Assays -- Application of Immunoassay Techniques in Psychopharmacology -- Drug Screening for Benzodiazepines, Antidepressants, and Neuroleptics -- In Vitro and Ex Vivo Neurochemical Screening Procedures for Antidepressants Neuroleptics Benzodiazepines -- Animal Models for Assessing Anxiolytic, Neuroleptic, and Antidepressant Drug Action -- High-Affinity Binding of Antidepressants to Platelets and Brain Tissues -- Structure-Activity Relationships at the Benzodiazepine Receptor. | |
| 520 | _aIn this volume, we hope to cover the malor techniques that are presently being used to analyze the actions of drugs used in psyc- atry. The contributors of the chapters are active researchers who have considerable practical experience with the techniques they are describing, and the emphasis in the chapters is on three types of psychiatric drugs, namely antidepressants, antipsychotics, and anxiolytics. The first chapter, by Curry and Yu, discusses protein binding of psychotropic drugs, with special reference to equilibrium ana- sis as the method of assessment and to lipophilicity correlations. Since many of the drugs used in treating psychiatric disorders are bound extensively to protein, this aspect is of great importance with regard to their therapeutic actions and toxicity, Basic mat- matical models, techniques for the study of protein binding, molecular aspects of protein binding, binding in relation to lipophilicity, indirect approaches to measurement of the fraction of drug bound, the function of protein binding, and tissue binding are among the topics discussed. Chapter 2, by Norman and B- rows, deals with the principles of isotope derivative assays and their applications to antidepressants and antipsychotics; extensive protocols are provided. The third chapter, by Cooper, deals with analysis by gas-liquid chromatography. Sample collection and storage, extraction procedures, column selection, use of internal standards, types of detectors, techniques of application, and - plications to specific drugs are among the topics discussed. | ||
| 532 | 8 | _aAccessibility summary: This PDF is not accessible. It is based on scanned pages and does not support features such as screen reader compatibility or described non-text content (images, graphs etc). However, it likely supports searchable and selectable text based on OCR (Optical Character Recognition). Users with accessibility needs may not be able to use this content effectively. Please contact us at accessibilitysupport@springernature.com if you require assistance or an alternative format. | |
| 532 | 8 | _aInaccessible, or known limited accessibility | |
| 532 | 8 | _aNo reading system accessibility options actively disabled | |
| 532 | 8 | _aPublisher contact for further accessibility information: accessibilitysupport@springernature.com | |
| 650 | 0 | _aNeurosciences. | |
| 650 | 1 | 4 | _aNeuroscience. |
| 700 | 1 |
_aBoulton, Alan A. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt |
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| 700 | 1 |
_aBaker, Glen B. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt |
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| 700 | 1 |
_aCoutts, Ronald T. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt |
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| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer Nature eBook | |
| 776 | 0 | 8 |
_iPrinted edition: _z9780896031210 |
| 776 | 0 | 8 |
_iPrinted edition: _z9781489941084 |
| 776 | 0 | 8 |
_iPrinted edition: _z9781489941091 |
| 830 | 0 |
_aNeuromethods, _x1940-6045 ; _v10 |
|
| 856 | 4 | 0 | _uhttps://doi.org/10.1385/0896031217 |
| 912 | _aZDB-2-PRO | ||
| 999 |
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