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001 978-1-60761-529-3
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005 20260610083649.0
007 cr nn 008mamaa
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020 _a9781607615293
_9978-1-60761-529-3
024 7 _a10.1007/978-1-60761-529-3
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aSCI089000
_2bisacsh
072 7 _aPSAN
_2thema
082 0 4 _a612.8
_223
245 1 0 _aDrug Delivery to the Central Nervous System
_h[electronic resource] /
_cedited by Kewal K. Jain.
250 _a1st ed. 2010.
264 1 _aTotowa, NJ :
_bHumana Press :
_bImprint: Humana,
_c2010.
300 _aXII, 324 p. 98 illus., 4 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aNeuromethods,
_x1940-6045 ;
_v45
505 0 _aAn Overview of Drug Delivery to the CNS -- Receptor-Mediated Transport of Drugs Across the BBB -- Disruption of Blood–Brain Barrier by Focused Ultrasound for Targeted Drug Delivery to the Brain -- Prediction of Blood–Brain Barrier Penetration by Drugs -- Intraparenchymal Delivery and Its Discontents -- Intrathecal Drug Delivery by Implanted Pumps -- Intracarotid Drug Delivery: Revisiting the Past or Looking into the Future -- Vesicular Systems for Intranasal Drug Delivery -- Convection-Enhanced Drug Delivery and Monitoring in a Rat Model -- Intrathecal Delivery of Stem Cells to the Spinal Cord -- CNS Delivery of Peptides Across the BBB Using the Dual-Artery In Situ Brain Perfusion Model -- An Engineered Peptide Compound Platform Technology Incorporating Angiopep for Crossing the BBB -- Adeno-Associated Virus Mediated Gene Therapy in Ischemic Stroke -- Use of Mesenchymal Stem Cells for Gene Delivery to Intracranial Glioma -- Convection-Enhanced Drug Delivery to the Brain.
520 _aPlaying an important role in the treatment of neurological disorders, the delivery of drugs to central nervous system (CNS), both administered directly and administered systematically for targeted action, encounters a major challenge in the form of the blood-brain barrier (BBB), which limits the access of drugs to the brain substance. In Drug Delivery to the Central Nervous System, experts in the field present essential methods used to deliver therapeutics across the BBB, both in experimental animals and in humans. In addition to those methods, several overviews of innovative methods and their applications are presented in order to give a glimpse of the future of this research. As a volume in the successful Neuromethods series, this book presents its protocols with the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Drug Delivery to the Central Nervous System serves as an ideal guide to scientists continuing to pursue knowledge of the delicate interactions between pharmaceuticals and the brain.
650 0 _aNeurosciences.
650 0 _aNeurochemistry.
650 1 4 _aNeuroscience.
650 2 4 _aNeurochemistry.
700 1 _aJain, Kewal K.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781607615286
776 0 8 _iPrinted edition:
_z9781607615316
776 0 8 _iPrinted edition:
_z9781493961597
830 0 _aNeuromethods,
_x1940-6045 ;
_v45
856 4 0 _uhttps://doi.org/10.1007/978-1-60761-529-3
912 _aZDB-2-PRO
999 _c6619
_d6619