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020 _a9781493929962
_9978-1-4939-2996-2
024 7 _a10.1007/978-1-4939-2996-2
_2doi
050 4 _aRM300-666
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
072 7 _aMKG
_2thema
082 0 4 _a615
_223
245 1 0 _aProcess Simulation and Data Modeling in Solid Oral Drug Development and Manufacture
_h[electronic resource] /
_cedited by Marianthi G. Ierapetritou, Rohit Ramachandran.
250 _a1st ed. 2016.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Humana,
_c2016.
300 _aX, 393 p. 131 illus., 96 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Pharmacology and Toxicology,
_x1940-6053
505 0 _aApplications of Modeling in Oral Solid Dosage Form Development and Manufacturing -- Population Balance Models for Pharmaceutical Processes -- A Quantitative Approach to Understand Raw Material Variability -- Discrete Element Modeling of Solid Dosage Manufacturing Processes -- A Procedure for Developing Quantitative Near Infrared (NIR) Methods for Pharmaceutical Products -- Advanced Process Decision Making Using Multivariate Latent Variable Methods -- Advanced Control of Continuous Pharmaceutical Tablet Manufacturing Processes -- Mathematical Tools for the Quantitative Definition of a Design Space -- Optimization Methodologies for the Production of Pharmaceutical Products -- An Overview of Pharmaceutical Manufacturing for Solid Dosage Forms.
520 _aThis thorough volume aims to provide pharmaceutical engineers with an introduction to the current state of the art in modeling and simulation of pharmaceutical processes and to summarize a number of practical applications of relevant methodologies in drug product development. Chapters include explorations of simulation and modeling methodologies, data collection and analysis, development of novel sensing techniques, development and integration of individual unit models, optimization approaches for data-based models, design space evaluation techniques, informatics-based methodologies, and emerging topics in pharmaceutical process development. As a part of the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and implementation advice that will make the transition into the laboratory as smooth as possible.   Authoritative and cutting edge, Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture seeks to promote research into process systems methodologies and their application in pharmaceutical product and process development, which will undoubtedly become an increasingly important area in the future.
650 0 _aPharmacology.
650 1 4 _aPharmacology.
700 1 _aIerapetritou, Marianthi G.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aRamachandran, Rohit.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781493929955
776 0 8 _iPrinted edition:
_z9781493929979
776 0 8 _iPrinted edition:
_z9781493949960
830 0 _aMethods in Pharmacology and Toxicology,
_x1940-6053
856 4 0 _uhttps://doi.org/10.1007/978-1-4939-2996-2
912 _aZDB-2-PRO
999 _c6617
_d6617