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020 _a9781071633663
_9978-1-0716-3366-3
024 7 _a10.1007/978-1-0716-3366-3
_2doi
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072 7 _aMJCM
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072 7 _aMED044000
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072 7 _aMJCM
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082 0 4 _a571.96
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245 1 0 _aToll-Like Receptors
_h[electronic resource] :
_bMethods and Protocols /
_cedited by Francesca Fallarino, Marco Gargaro, Giorgia Manni.
250 _a1st ed. 2023.
264 1 _aNew York, NY :
_bSpringer US :
_bImprint: Humana,
_c2023.
300 _aXI, 286 p. 45 illus., 42 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
341 0 _bTable of contents navigation
_2onix
341 0 _bSingle logical reading order
_2onix
341 0 _bShort alternative textual descriptions
_2onix
341 0 _bUse of color is not sole means of conveying information
_2onix
341 0 _bUse of high contrast between text and background color
_2onix
341 0 _bNext / Previous structural navigation
_2onix
341 0 _bAll non-decorative content supports reading without sight
_2onix
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Molecular Biology,
_x1940-6029 ;
_v2700
505 0 _aModelling of transmembrane domain and full length TLRs in membrane models -- Development of Optimal Virtual Screening Strategies to Identify Novel Toll-like Receptor Ligands using the DockBox Suite -- Use of Fluorescent Chemical Probes in the Study of Toll-like Receptors (TLRs) Trafficking -- Use of Fluorescent Chemical Probes in the Study of Toll-like Receptors (TLRs) Trafficking -- Endotoxin-tolerance mimicking to study TLR in promotion of tolerogenic DCs and Tr1 cells -- Flow cytometry analysis of IL-1 receptors and Toll like receptors on platelets and platelet-derived extracellular vesicles -- Methods to study TLRs in transplantation -- Determining endosomal Toll-like Receptors gene expression in NK cells after stimulation with specific agonists -- In vitro study of TLR4-NLRP3-inflammasome activation pathway in innate immune response -- Toll-like receptor polymorphisms and the risk of cancer: meta-analysis study -- Unrevealing the role of TLRs in the pathogenesis of autoimmune disease by using mouse model of diabetes -- In vitro and ex vivo methodologies for T cell trafficking through Blood Brain Barrier after TLR activation -- Delineating the role of Toll-like receptors in inflammatory bowel disease -- Analysis of differential TLR activation in a mouse model of multiple sclerosis -- Study of agonists of TLRs as vaccine adjuvants -- Activation of TLRs by opportunistic fungi in lung organoids. .
520 _aThis volume provides methods on the role of TLRs in immune responses and on the various approaches targeting different TLRs in cancer, autoimmunity and in vaccine development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Toll-Like Receptors: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge. .
532 8 _aAccessibility summary: This PDF does not fully comply with PDF/UA standards, but does feature limited screen reader support, described non-text content (images, graphs), bookmarks for easy navigation and searchable, selectable text. Users of assistive technologies may experience difficulty navigating or interpreting content in this document. We recognize the importance of accessibility, and we welcome queries about accessibility for any of our products. If you have a question or an access need, please get in touch with us at accessibilitysupport@springernature.com.
532 8 _aNo reading system accessibility options actively disabled
532 8 _aPublisher contact for further accessibility information: accessibilitysupport@springernature.com
650 0 _aImmunology.
650 0 _aCancer.
650 1 4 _aImmunology.
650 2 4 _aCancers.
700 1 _aFallarino, Francesca.
_eeditor.
_0(orcid)0000-0002-8501-2136
_1https://orcid.org/0000-0002-8501-2136
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aGargaro, Marco.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aManni, Giorgia.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781071633656
776 0 8 _iPrinted edition:
_z9781071633670
776 0 8 _iPrinted edition:
_z9781071633687
830 0 _aMethods in Molecular Biology,
_x1940-6029 ;
_v2700
856 4 0 _uhttps://doi.org/10.1007/978-1-0716-3366-3
912 _aZDB-2-PRO
999 _c6465
_d6465