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020 _a9781493966615
_9978-1-4939-6661-5
024 7 _a10.1007/978-1-4939-6661-5
_2doi
050 4 _aRM300-666
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
072 7 _aMKG
_2thema
082 0 4 _a615
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245 1 0 _aStem Cell-Derived Models in Toxicology
_h[electronic resource] /
_cedited by Mike Clements, Liz Roquemore.
250 _a1st ed. 2017.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Humana,
_c2017.
300 _aXII, 341 p. 124 illus., 108 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Pharmacology and Toxicology,
_x1940-6053
505 0 _aStem Cell‐Derived Models for Safety and Toxicity Assessments: Present and Future Studies in the “Proclinical Space” -- Human Pluripotent Stem Cell Test for Assessing the Potential Teratogen Risk -- Cardiac Action Potential Measurement in Human Embryonic Stem Cell Cardiomyocytes for Cardiac Safety Studies Using Manual Patch-Clamp Electrophysiology -- Automated Patch Clamp Recordings of Human Stem Cell-Derived Cardiomyocytes -- The CiPA Microelectrode Array Assay with hSC-Derived Cardiomyocytes: Current Protocol, Future Potential -- Optogenetic Approach to Cardiotoxicity Screening: Simultaneous Voltage and Calcium Imaging Under Paced Conditions -- HTS Compatible Voltage- and Ca2+-Sensitive Dye Recordings from hiPSC-Derived Cardiomyocytes Using the Hamamatsu FDSS Systems -- Kinetic Image Cytometry for Predicting Arrhythmias Using Human Stem Cell-Derived Cardiomyocytes -- Decoding Ca2+ Signals as a Non-Electrophysiological Method forAssessing Drug Toxicity in Stem-Cell Derived Cardiomyocytes -- Combined Impedance and Extracellular Field Potential Recordings from Human Stem Cell-Derived Cardiomyocytes -- Edge Detection for Contractility Measurements with Cardiac Spheroids -- Contractile Force Readout of hESC-Cardiomyocytes -- In Vitro Cardiotoxicity Investigation Using High Content Analysis and Human Stem Cell-Derived Models -- Structural Toxicity: Hypertrophy Models of Human Pluripotent Stem Cell-Derived Cardiomyocytes -- Addressing Functional Neurotoxicity Using the Microelectrode Array (MEA) -- Micropatterned Co-Cultures of Induced Pluripotent Stem Cell-Derived Hepatocytes and Stromal Cells for Drug Toxicity Studies.
520 _aThis detailed volume brings together a diverse collection of stem cell-derived model-based toxicity assays, from those routinely used to those deemed to have considerable potential. With a focus on differentiated tissues, the chapters explore numerous cardiotoxicity applications as well as coverage of neurotoxicity, hepatotoxicity, and more. Written for the Methods in Pharmacology and Toxicology series, the contents of this book aim to enable adoption of these protocols in laboratories that are interested in entering the field as well as to facilitate the transfer of best practices between laboratories that are already actively pursuing these technologies. Authoritative and cutting-edge, Stem Cell-Derived Models in Toxicology serves as a vital resource for researchers aiming to improve risk assessment in drug discovery and design.
650 0 _aPharmacology.
650 1 4 _aPharmacology.
700 1 _aClements, Mike.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aRoquemore, Liz.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781493966592
776 0 8 _iPrinted edition:
_z9781493966608
776 0 8 _iPrinted edition:
_z9781493982646
830 0 _aMethods in Pharmacology and Toxicology,
_x1940-6053
856 4 0 _uhttps://doi.org/10.1007/978-1-4939-6661-5
912 _aZDB-2-PRO
999 _c6180
_d6180