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001 978-1-60761-274-2
003 DE-He213
005 20260610083642.0
007 cr nn 008mamaa
008 100715s2009 xxu| s |||| 0|eng d
020 _a9781607612742
_9978-1-60761-274-2
024 7 _a10.1007/978-1-60761-274-2
_2doi
050 4 _aQD415-436
072 7 _aPSB
_2bicssc
072 7 _aSCI007000
_2bisacsh
072 7 _aPSB
_2thema
082 0 4 _a572
_223
245 1 0 _aChemogenomics
_h[electronic resource] :
_bMethods and Applications /
_cedited by Edgar Jacoby.
250 _a1st ed. 2009.
264 1 _aTotowa, NJ :
_bHumana Press :
_bImprint: Humana,
_c2009.
300 _aX, 320 p. 107 illus.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Molecular Biology,
_x1940-6029 ;
_v575
505 0 _aOrganizing Bioactive Compound Discovery in Target Families -- Compound Library Design for Target Families -- Targeting the Purinome -- Cofactor Chemogenomics -- Chemogenomics with Protein Secondary-Structure Mimetics -- Database Systems for Knowledge-Based Discovery -- Knowledge-Based Virtual Screening: Application to the MDM4/p53 Protein–Protein Interaction -- Off-Target Networks Derived from Ligand Set Similarity -- Chemogenomic Analysis of Safety Profiling Data -- Network and Pathway Analysis of Compound–Protein Interactions -- The Flexible Pocketome Engine for Structural Chemogenomics -- Structure-Based Chemogenomics: Analysis of Protein Family Landscapes -- Hypothesis-Driven Screening.
520 _aThe establishment, analysis, prediction, and expansion of a comprehensive ligand-target Structure-Activity Relationship (SAR) in the post-genomic era presents a key research challenge for this century. In Chemogenomics: Methods and Applications, experts from academia and industry explore cutting-edge in vitro and in silico approaches available today and outline the relevant aspects of chemistry, biology, and molecular informatics which are the cornerstones of chemogenomics, thus combining introductory concepts with detailed methods and protocols. Covering topics such as target family-oriented compound library design, drug discovery targeting the purinome and co-factor binding sites, as well as the pocketome engine and molecular interaction field approaches, the book emphasizes systemization as an advantage to furthering the difficult science of drug discovery. As a volume in the highly successful Methods in Molecular Biology™ series format, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and practical, Chemogenomics: Methods and Applications presents content which will be of enormous value to those striving for the discovery of new and better therapies for diseases.
650 0 _aBiochemistry.
650 0 _aMedical genetics.
650 0 _aAnalytical chemistry.
650 0 _aBioinformatics.
650 1 4 _aBiochemistry.
650 2 4 _aMedical Genetics.
650 2 4 _aAnalytical Chemistry.
650 2 4 _aComputational and Systems Biology.
700 1 _aJacoby, Edgar.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781607612735
776 0 8 _iPrinted edition:
_z9781607612759
776 0 8 _iPrinted edition:
_z9781617796395
830 0 _aMethods in Molecular Biology,
_x1940-6029 ;
_v575
856 4 0 _uhttps://doi.org/10.1007/978-1-60761-274-2
912 _aZDB-2-PRO
999 _c6174
_d6174