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020 _a9781071611548
_9978-1-0716-1154-8
024 7 _a10.1007/978-1-0716-1154-8
_2doi
050 4 _aQD431-431.7
072 7 _aPSBC
_2bicssc
072 7 _aSCI049000
_2bisacsh
072 7 _aPSB
_2thema
082 0 4 _a572.6
_223
245 1 0 _aAllostery
_h[electronic resource] :
_bMethods and Protocols /
_cedited by Luisa Di Paola, Alessandro Giuliani.
250 _a1st ed. 2021.
264 1 _aNew York, NY :
_bSpringer US :
_bImprint: Humana,
_c2021.
300 _aXII, 274 p. 99 illus., 91 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Molecular Biology,
_x1940-6029 ;
_v2253
505 0 _aAllostery: The Rebound of Proteins -- Disclosing Allostery Through Protein Contact Networks -- Identification of Allosteric Effects in Proteins by Elastic Network Models -- Locating and Navigating Energy Transport Networks in Proteins -- Probing Allosteric Mechanism with Long-Range Rigidity Transmission across Protein Networks -- Protein Assembly: Defining the Strength of Protein-Protein Interactions Coupling the Theory with Experiments -- Network Re-Wiring during Allostery and Protein-Protein Interactions: A Graph Spectral Approach -- Topology Results on Adjacent Amino Acid Networks of Oligomeric Proteins -- Community Network Analysis of Allosteric Proteins -- The PyInteraph Workflow for the Study of Interaction Networks Form Protein Structural Ensembles -- The Allosteric Effect in Antibody-Antigen Recognition -- Distal Regions Regulate Dihydrofolate Reductase-Ligand Interactions -- Investigating Conformational Dynamics and Allostery in the p53 DNA-Binding Domain Using Molecular Simulations -- Molecular Dynamics Simulation Techniques as a Tool in Drug Discovery and Pharmacology: A Focus on Allosteric Drugs -- Cooperativity and Allostery in RNA Systems.
520 _aThis volume explores the basic issues of “allostery” and “network” that are fundamental to studying this field. Chapters in this book look at how the basic “machine-like” proteins, that are similar to “human machines,” need to be organized, architecturally, to relate to different organizational layers. Chapters cover topics such as methodological/computational factors focused on links between allostery and network formalism; the presence of oscillating modes transversing the structure and underlying network wiring of the allosteric process; the “action at distance” by transduction of signals across an organized network structure; and the P53 protein located at the cross-road of cell cycle regulation, genome integrity, and cancer development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Allostery: Methods and Protocols is a valuable resource for any scientists and researcher interested in learning more about this developing field. .
650 0 _aProteins .
650 1 4 _aProtein Biochemistry.
700 1 _aDi Paola, Luisa.
_eeditor.
_0(orcid)0000-0001-5329-8689
_1https://orcid.org/0000-0001-5329-8689
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aGiuliani, Alessandro.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781071611531
776 0 8 _iPrinted edition:
_z9781071611555
776 0 8 _iPrinted edition:
_z9781071611562
830 0 _aMethods in Molecular Biology,
_x1940-6029 ;
_v2253
856 4 0 _uhttps://doi.org/10.1007/978-1-0716-1154-8
912 _aZDB-2-PRO
999 _c6040
_d6040