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020 _a9781071633076
_9978-1-0716-3307-6
024 7 _a10.1007/978-1-0716-3307-6
_2doi
050 4 _aRC346-429.2
072 7 _aPSAN
_2bicssc
072 7 _aSCI089000
_2bisacsh
072 7 _aPSAN
_2thema
082 0 4 _a616.8
_223
245 1 0 _aSchizophrenia
_h[electronic resource] :
_bMethods and Protocols /
_cedited by Leyre Urigüen, Rebeca Díez-Alarcia.
250 _a1st ed. 2023.
264 1 _aNew York, NY :
_bSpringer US :
_bImprint: Humana,
_c2023.
300 _aX, 155 p. 25 illus., 19 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
341 0 _bTable of contents navigation
_2onix
341 0 _bSingle logical reading order
_2onix
341 0 _bShort alternative textual descriptions
_2onix
341 0 _bUse of color is not sole means of conveying information
_2onix
341 0 _bUse of high contrast between text and background color
_2onix
341 0 _bNext / Previous structural navigation
_2onix
341 0 _bAll non-decorative content supports reading without sight
_2onix
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Molecular Biology,
_x1940-6029 ;
_v2687
505 0 _aA Novel Method to Estimate Levels of Receptors Using an Allosteric Modulator. Focus on muscarinic M1 receptors -- Enhanced bystander BRET (ebBRET) biosensors as biophysical tools to map the signaling profile of neuropsychiatric drugs targeting GPCR -- [35S]GTPγS (Guanosine-5′-O-(γ-thio)triphosphate-[35S]) Binding Scintillation Proximity Assay experiments in postmortem brain tissue -- CRISPR/Cas9 as a simple technique for the generation of murine knockout models for neuropsychiatric diseasesEvaluation of sensory-motor gating deficits in mice th -- rough prepulse inhibition (PPI) of the startle response -- Automated detection of psychedelic-induced head twitch response in mice -- Gastrointestinal and microbiome profiling in rodent models of neurological and psychiatric disorders -- Electroencephalography for the study of the auditory P300 evoked potential and derived measurements -- Quantification of endocannabinoids in human plasma -- Neuropsychological and functional assessment of cognitive impairments in schizophrenia -- Clinical management and assessment of the early stages of psychosis: a multidimensional approach.
520 _aThis volumes presents current methods used in the research of schizophrenia. Chapters guide readers through molecular techniques, in vivo approaches, cell cultures and heterologous expression systems, and even research methods involving human studies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Schizophrenia: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
532 8 _aAccessibility summary: This PDF does not fully comply with PDF/UA standards, but does feature limited screen reader support, described non-text content (images, graphs), bookmarks for easy navigation and searchable, selectable text. Users of assistive technologies may experience difficulty navigating or interpreting content in this document. We recognize the importance of accessibility, and we welcome queries about accessibility for any of our products. If you have a question or an access need, please get in touch with us at accessibilitysupport@springernature.com.
532 8 _aNo reading system accessibility options actively disabled
532 8 _aPublisher contact for further accessibility information: accessibilitysupport@springernature.com
650 0 _aNervous system
_xDiseases.
650 0 _aNeuropharmacology.
650 1 4 _aNeurological Disorders.
650 2 4 _aNeuropharmacology.
700 1 _aUrigüen, Leyre.
_eeditor.
_0(orcid)0000-0002-1296-6895
_1https://orcid.org/0000-0002-1296-6895
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aDíez-Alarcia, Rebeca.
_eeditor.
_0(orcid)0000-0002-0806-9825
_1https://orcid.org/0000-0002-0806-9825
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781071633069
776 0 8 _iPrinted edition:
_z9781071633083
776 0 8 _iPrinted edition:
_z9781071633090
830 0 _aMethods in Molecular Biology,
_x1940-6029 ;
_v2687
856 4 0 _uhttps://doi.org/10.1007/978-1-0716-3307-6
912 _aZDB-2-PRO
999 _c5968
_d5968