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020 _a9781071649855
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024 7 _a10.1007/978-1-0716-4985-5
_2doi
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050 4 _aQH315-320
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072 7 _aMED106000
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072 7 _aMBGR
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082 0 4 _a610.72
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245 1 0 _aPhenotypic Screening
_h[electronic resource] :
_bMethods and Protocols /
_cedited by Sebastian Dunst, Verena Fetz.
250 _a1st ed. 2026.
264 1 _aNew York, NY :
_bSpringer US :
_bImprint: Humana,
_c2026.
300 _aXII, 340 p. 54 illus., 48 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
341 0 _bPDF/UA-1
_2onix
341 0 _bTable of contents navigation
_2onix
341 0 _bSingle logical reading order
_2onix
341 0 _bShort alternative textual descriptions
_2onix
341 0 _bUse of color is not sole means of conveying information
_2onix
341 0 _bUse of high contrast between text and background color
_2onix
341 0 _bNext / Previous structural navigation
_2onix
341 0 _bAll non-decorative content supports reading without sight
_2onix
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Molecular Biology,
_x1940-6029 ;
_v2989
505 0 _aHigh-Content Screening Framework for Academic Early Drug Discovery -- The Cell Painting PLUS Assay: Phenotypic Profiling Using Iterative Staining-Elution Cycles -- Analyzing Cell Painting PLUS Data Using Cell Profiler and KNIME Analytics Platform -- Cell Painting Protocol to Characterize Morphological Profiles of Large Compound Collections Using the EU-OPENSCREEN Library -- The E-Morph Screening Assay: Phenotypic Screening for Estrogenic or Anti-Estrogenic Compound Activities -- Phenotypic Characterization Using Open-Source Deep Learning Tools -- Quality Control Measures and Statistical Strategies to Address the Challenges of High-Content Phenotypic Data -- Morphological Data Analysis: From Descriptor Development to Predictive Modeling -- Digital Holographic Microscopy for Phenotypic Profiling of Adherent Cells -- Semi-Automated Detection of Late Cytokinetic Bridges -- Phenotypic Drug Screening for Novel Antifibrotic Therapeutics in Lung Health -- Spinal Spheroids as Screening Platform for Peripheral Neuropathies -- A Head and Neck Cancer Spheroid Model for Phenotypic High-Content Screening of Chemoresistance -- Dissecting Bacterial Growth Variants by Cellular Phenotypic Profiling and Backtracing -- Large-Scale Mutagenesis Screening for Genetic Determinants of Plasmodium falciparum Sexual Development -- High-Throughput Phenotypic and Metabolic Screening of Wild Yeasts for Their Biotechnological Application -- Invertebrate Automated Phenotyping Platform (INVAPP): An Automated High-Throughput System with Applications in Understanding and Combating Human Diseases -- CRISPR/Cas9-Based Mutagenesis Strategies for Efficient Biallelic Gene Inactivation and Consistent Phenotypic Detection in F0 Zebrafish.
520 _aThis detailed volume explores recent advances in phenotypic screening, such as high-resolution microscopy, high-throughput screening, and artificial intelligence (AI)-based image and data analysis tools. The methodologies found within the book enable the characterization of pathomechanisms of human diseases, support the targeted development of novel drugs and personalized medicine, and also aid in the development of novel chemicals to combat human parasites or to identify undesired effects caused by environmental pollutants. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and practical, Phenotypic Screening: Methods and Protocols serves as an ideal guide to this growing field that touches areas of basic and translational biomedical research, clinical and pharmaceutical research, biotechnology, toxicology, and bioinformatics. Chapters 2, 3, 4, 5, 6, 7, 8, and 18 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
532 8 _aAccessibility summary: This PDF has been created in accordance with the PDF/UA-1 standard to enhance accessibility, including screen reader support, described non-text content (images, graphs), bookmarks for easy navigation, keyboard-friendly links and forms and searchable, selectable text. We recognize the importance of accessibility, and we welcome queries about accessibility for any of our products. If you have a question or an access need, please get in touch with us at accessibilitysupport@springernature.com. Please note that a more accessible version of this eBook is available as ePub.
532 8 _aNo reading system accessibility options actively disabled
532 8 _aPublisher contact for further accessibility information: accessibilitysupport@springernature.com
650 0 _aMedicine
_xResearch.
650 0 _aBiology
_xResearch.
650 0 _aPharmacology.
650 0 _aCytology.
650 1 4 _aBiomedical Research.
650 2 4 _aPharmacology.
650 2 4 _aCell Biology.
700 1 _aDunst, Sebastian.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aFetz, Verena.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781071649848
776 0 8 _iPrinted edition:
_z9781071649862
776 0 8 _iPrinted edition:
_z9781071649879
830 0 _aMethods in Molecular Biology,
_x1940-6029 ;
_v2989
856 4 0 _uhttps://doi.org/10.1007/978-1-0716-4985-5
912 _aZDB-2-PRO
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