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001 978-1-0716-0171-6
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008 200106s2020 xxu| s |||| 0|eng d
020 _a9781071601716
_9978-1-0716-0171-6
024 7 _a10.1007/978-1-0716-0171-6
_2doi
050 4 _aRS400-431
072 7 _aPSB
_2bicssc
072 7 _aSCI013040
_2bisacsh
072 7 _aPNB
_2thema
082 0 4 _a615.19
_223
245 1 0 _aImmuno-Oncology
_h[electronic resource] :
_bCellular and Translational Approaches /
_cedited by Seng-Lai Tan.
250 _a1st ed. 2020.
264 1 _aNew York, NY :
_bSpringer US :
_bImprint: Humana,
_c2020.
300 _aX, 262 p. 91 illus., 83 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Pharmacology and Toxicology,
_x1940-6053
505 0 _aAn In Vitro System Combining Tumor Cells and Lymphocytes to Predict the In Vivo Response of Immunomodulatory Antibodies -- High-Throughput Direct Cell Counting Method for Immuno-Oncology Functional Assays Using Image Cytometry -- In Vitro Immunotherapy Potency Assays Using Real-Time Cell Analysis -- Assessing the Potency of T Cell-Redirecting Therapeutics Using In Vitro Cancer Cell Killing Assays -- Induction and Potential Reversal of a T Cell Exhaustion-Like State: In Vitro Potency Assay for Functional Screening of Immune Checkpoint Drug Candidates -- Validation of an Image-Based 3D Natural Killer Cell-Mediated Cytotoxicity Assay -- 3D-3-Culture: Tumor Models to Study Heterotypic Interactions in the Tumor Microenvironment -- Considerations in Developing Reporter Gene Bioassays for Biologics -- Miniaturized Single Cell Imaging for Developing Immuno-Oncology Combinational Therapies -- Precision Medicine: The Function of Receptor Occupancy in Drug Development -- In Vitro Assays for Assessing Potential Adverse Effects of Cancer Immunotherapeutics -- The Quest for the Next-Generation of Tumor Targets: Discovery and Prioritization in the Genomics Era.
520 _aThis book serves as a guide for identifying and applying commonly used cell-based translational assays as well as for assessing the therapeutic potential of new immuno-oncology therapeutics and advancing their mechanism of action. The detailed chapters within will provide readers with a baseline understanding of the pros and cons as well as key considerations for applying assays that are more reflective of the human immune-tumor microenvironment in order to increase their translatability into the clinic. Written for the Methods in Pharmacology and Toxicology series, the contents of this volume include the kind of specifics and real-world implementation advice to ensure success in the lab. Authoritative and practical, Immuno-Oncology: Cellular and Translational Approaches aims to aid researchers working on biotechnology and pharmaceutical efforts to search for the next generation of safer and more effective cancer immunotherapeutics. The chapter “Considerations in Developing Reporter Gene Bioassays for Biologics” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
650 0 _aPharmaceutical chemistry.
650 0 _aCancer.
650 0 _aImmunology.
650 1 4 _aPharmaceutics.
650 2 4 _aCancer Biology.
650 2 4 _aImmunology.
700 1 _aTan, Seng-Lai.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781071601709
776 0 8 _iPrinted edition:
_z9781071601723
776 0 8 _iPrinted edition:
_z9781071601730
830 0 _aMethods in Pharmacology and Toxicology,
_x1940-6053
856 4 0 _uhttps://doi.org/10.1007/978-1-0716-0171-6
912 _aZDB-2-PRO
999 _c5715
_d5715