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020 _a9781071615799
_9978-1-0716-1579-9
024 7 _a10.1007/978-1-0716-1579-9
_2doi
050 4 _aRM300-666
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
072 7 _aMKG
_2thema
082 0 4 _a615
_223
245 1 0 _aGreen Chemistry in Drug Discovery
_h[electronic resource] :
_bFrom Academia to Industry /
_cedited by Paul F. Richardson.
250 _a1st ed. 2022.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Humana,
_c2022.
300 _aXVI, 617 p. 609 illus., 19 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Pharmacology and Toxicology,
_x1940-6053
505 0 _aGreen Synthesis of Common Heterocycles -- Greener Methods for Amide Bond Synthesis -- Mitsunobu Reactions in Medicinal Chemistry and Development of Practical Modifications -- Direct Nucleophilic Substitution of Alcohols by Brønsted or Lewis Acids Activation: An Update -- Friedel-Crafts Reactions -- Ionic Liquids: Design and Applications -- Designing Efficient Cascade Reactions in Drug Discovery -- Multicomponent Synthesis: Cohesive Integration of Green Chemistry Principles -- Direct C–H Functionalization Approaches to Pharmaceutically Relevant Molecules -- C–H Activation with Photoredox Catalysis -- In Situ Protecting Groups for Chemoselective Transformations -- Expanding the Biocatalysis Toolbox -- New Directions in Coupling Chemistry -- Flow Chemistry as an Enabling Technology for Synthetic Organic Chemistry -- Reaction Optimization: A High-Throughput Experimentation Approach -- Radiopharmaceutical Discovery with 11CO2-Fixation Methods Inspired by Green Chemistry.
520 _aThis detailed book highlights several emerging areas in the implementation of green chemistry in medicinal chemistry drug discovery with a specific focus on their application to the expeditious discovery of new biologically active entities. Divided into three sections, the collection explores greener approaches to chemical transformations that are both prevalent and have been highlighted as challenging within the pharmaceutical industry, overall synthetic strategy, as well as the implementation and impact of a range of enabling technologies within medicinal chemistry. As a volume of the Methods in Pharmacology and Toxicology series, chapters provide the kind of key insight that can guide researchers toward greater success in the lab. Authoritative and practical, Green Chemistry in Drug Discovery: From Academia to Industry provides both a fundamental insight into the progress that has been made as well as some of the challenges that still exist forthese techniques to be effectively implemented in the drug discovery process in a routine manner.
650 0 _aPharmacology.
650 0 _aGreen chemistry.
650 1 4 _aPharmacology.
650 2 4 _aGreen Chemistry.
700 1 _aRichardson, Paul F.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781071615775
776 0 8 _iPrinted edition:
_z9781071615782
776 0 8 _iPrinted edition:
_z9781071620335
830 0 _aMethods in Pharmacology and Toxicology,
_x1940-6053
856 4 0 _uhttps://doi.org/10.1007/978-1-0716-1579-9
912 _aZDB-2-PRO
999 _c5629
_d5629