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020 _a9781071613191
_9978-1-0716-1319-1
024 7 _a10.1007/978-1-0716-1319-1
_2doi
050 4 _aRC321-580
072 7 _aPSAN
_2bicssc
072 7 _aSCI089000
_2bisacsh
072 7 _aPSAN
_2thema
082 0 4 _a612.8
_223
245 1 0 _aCerebrospinal Fluid Biomarkers
_h[electronic resource] /
_cedited by Charlotte E. Teunissen, Henrik Zetterberg.
250 _a1st ed. 2021.
264 1 _aNew York, NY :
_bSpringer US :
_bImprint: Humana,
_c2021.
300 _aXII, 236 p. 67 illus., 34 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aNeuromethods,
_x1940-6045 ;
_v168
505 0 _aCSF Cell: Cell Count, Cytomorphology, Cytology, and Immunophenotyping -- Nephelometry and Turbidimetry: Methods to Quantify Albumin and Immunoglobins Concentrations in Clinical Neurochemistry -- Oligoclonal Bands: Isoelectric Focusing and Immunoblotting, and Determination of Free Light Chains in the Cerebrospinal Fluid -- Abeta CSF LC-MS -- Immunoassay and Mass Spectrometry Methods for Tau Protein Quantification in the Cerebrospinal Fluid -- CSF RT-QuIC and the Diagnosis of Creutzfeldt-Jakob Disease -- Lumbar Puncture: Consensus Guidelines -- Pre-Analytical Processing and Biobanking Protocol for CSF Samples -- Communicating Complex Results of Cerebrospinal Fluid Analysis -- Method and Clinical Validation of Biomarkers for Neurodegenerative Diseases -- Sample Preparation for Proteomic Analysis of Cerebrospinal Fluid -- Brain Biomarkers: Follow Up of RNA Expression Discovery Approach – CSF Assays for Neurogranin, SNAP-25, and VILIP-1 -- Quantification of the Neurofilament Light Chain Protein by Single Molecule Array (Simoa) Array.
520 _aThis volume covers the latest methods used in clinical neurochemistry laboratories for both clinical practice and research. Chapters in this book discuss topics such as techniques for cerebrospinal fluid (CSF) collection, pre-analytical processing, and basic CSF analysis; an examination of biomarkers including ELISA and automated immunochemical assays for amyloid and tau markers for Alzheimer’s disease; the analysis of neurofilaments by digital ELISA; and an example of successful novel immunoassay development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Cerebrospinal Fluid Biomarkers is a valuable resource for clinicians and researchers to use in CSF labs and CSF courses.
650 0 _aNeurosciences.
650 1 4 _aNeuroscience.
700 1 _aTeunissen, Charlotte E.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aZetterberg, Henrik.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781071613184
776 0 8 _iPrinted edition:
_z9781071613207
776 0 8 _iPrinted edition:
_z9781071613214
830 0 _aNeuromethods,
_x1940-6045 ;
_v168
856 4 0 _uhttps://doi.org/10.1007/978-1-0716-1319-1
912 _aZDB-2-PRO
999 _c5609
_d5609