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020 _a9781071600306
_9978-1-0716-0030-6
024 7 _a10.1007/978-1-0716-0030-6
_2doi
050 4 _aQD415-436
072 7 _aPSB
_2bicssc
072 7 _aSCI007000
_2bisacsh
072 7 _aPSB
_2thema
082 0 4 _a572
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245 1 0 _aIon Mobility-Mass Spectrometry
_h[electronic resource] :
_bMethods and Protocols /
_cedited by Giuseppe Paglia, Giuseppe Astarita.
250 _a1st ed. 2020.
264 1 _aNew York, NY :
_bSpringer US :
_bImprint: Humana,
_c2020.
300 _aXI, 312 p. 102 illus., 83 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Molecular Biology,
_x1940-6029 ;
_v2084
505 0 _aFundamentals of Ion Mobility-Mass Spectrometry for the Analysis of Biomolecules -- Utilizing Drift Tube Ion Mobility Spectrometry for the Evaluation of Metabolites and Xenobiotics -- Untargeted Differential Metabolomics Analysis Using Drift Tube Ion Mobility-Mass Spectrometry -- Drift Tube Ion Mobility-Mass Spectrometry for Non-Targeted 'Omics -- The Use of DMS-MS for the Quantitative Analysis of Acylcarnitines -- Traveling Wave Ion Mobility-Mass Spectrometry to Enhance the Detection of Low Abundance Features in Untargeted Lipidomics -- Lipidomics by HILIC-Ion Mobility-Mass Spectrometry -- A Workflow for the Identification of Mycotoxin Metabolites Using Liquid Chromatography–Ion Mobility-Mass Spectrometry -- Quantitation of Cyclosporin A in Cell Culture Media by Differential Mobility Mass Spectrometry (DMS-MS/MS) -- An Analytical Perspective on Protein Analysis and Discovery Proteomics by Ion Mobility-Mass Spectrometry -- Ion Mobility-Mass Spectrometry to Evaluate the Effects of Protein Modification or Small Molecule Binding on Protein Dynamics -- Liquid Extraction Surface Analysis (LESA) High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) Mass Spectrometry for In Situ Analysis of Intact Proteins -- Ion Mobility-Mass Spectrometry of Glycoconjugates -- Desorption Atmospheric Pressure Photoionization Coupled with Ion Mobility-Mass Spectrometry -- Metabolomic Profiling of Adherent Mammalian Cells In Situ by LAESI-MS with Ion Mobility Separation -- Matrix-Assisted Laser Desorption and Desorption Electrospray Ionization Mass Spectrometry Coupled to Ion Mobility -- The Use of LipidIMMS Analyzer for Lipid Identification in Ion Mobility-Mass Spectrometry-Based Untargeted Lipidomics -- MolFind2: A Protocol for Acquiring and Integrating MS3 Data to Improve In-Silico Chemical Structure Elucidation for Metabolomics -- Collision Cross Section Calculations Using HPCCS.
520 _aThis book focuses on ion mobility-mass spectrometry (IM-MS) and informatics approaches to improve traditional analysis of molecules by providing fundamentals and protocols for exploiting the potential of state-of-the-art IM-MS technology for the most common analytical applications. The chapters have been organized into four parts, each dealing with a particular set of IM-MS applications: 1) metabolomics and lipidomics; 2) proteomics and glycomics; 3) imaging and ambient ionization IM-MS; and 4) bioinformatic solutions for analyzing IM-MS data and deriving CCS values. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Ion Mobility-Mass Spectrometry: Methods and Protocols serves as anideal resource for scientists delving into the technique's unprecedented analytical advantages, enabling novel qualitative and quantitative applications for the analysis of complex biological samples.
650 0 _aBiochemistry.
650 0 _aMass spectroscopy.
650 1 4 _aBiochemistry.
650 2 4 _aMass Spectrometry.
700 1 _aPaglia, Giuseppe.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aAstarita, Giuseppe.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781071600290
776 0 8 _iPrinted edition:
_z9781071600313
776 0 8 _iPrinted edition:
_z9781071600320
830 0 _aMethods in Molecular Biology,
_x1940-6029 ;
_v2084
856 4 0 _uhttps://doi.org/10.1007/978-1-0716-0030-6
912 _aZDB-2-PRO
999 _c5338
_d5338