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020 _a9781071649763
_9978-1-0716-4976-3
024 7 _a10.1007/978-1-0716-4976-3
_2doi
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_2bicssc
072 7 _aMED106000
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072 7 _aMKGT
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082 0 4 _a615.90072
_223
245 1 0 _aGenotoxicity Assessment
_h[electronic resource] :
_bMethods and Protocols /
_cedited by Alok Dhawan, Mahima Bajpayee.
250 _a3rd ed. 2026.
264 1 _aNew York, NY :
_bSpringer US :
_bImprint: Humana,
_c2026.
300 _aXXV, 642 p. 154 illus., 112 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
341 0 _bPDF/UA-1
_2onix
341 0 _bTable of contents navigation
_2onix
341 0 _bSingle logical reading order
_2onix
341 0 _bShort alternative textual descriptions
_2onix
341 0 _bUse of color is not sole means of conveying information
_2onix
341 0 _bUse of high contrast between text and background color
_2onix
341 0 _bNext / Previous structural navigation
_2onix
341 0 _bAll non-decorative content supports reading without sight
_2onix
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Molecular Biology,
_x1940-6029 ;
_v2986
505 0 _aBacterial Reverse Mutation Test - Ames Test -- The AMES II and Ames MPFTM Tests: Miniaturized Liquid Microplate Formats of the Ames Test in Petri Dishes -- In Vitro Mouse Lymphoma Cell (L5178Y Tk+/- -3.7.2.C) Forward Mutation Assay -- Erythrocyte-Based Pig-a Gene Mutation Assay -- Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes -- In Vitro Cytogenetic Assays: Chromosomal Aberrations and Micronucleus Tests -- In Vivo Micronucleus and Chromosomal Aberration Assay in Mouse Bone Marrow -- Chromosomal Aberration Test in Human Lymphocytes -- Micronucleus Assay in Human Lymphocytes and Exfoliated Buccal Cells -- 3D Liver Models for Genotoxicity Testing -- Flow Cytometric Determination of Micronucleus Frequency -- Comparative Genomic Hybridization (CGH) in Genotoxicology: From the Basics to Modern Approaches -- 32P-Postlabeling Analysis of DNA Adducts -- Multicolor Laser Scanning Confocal Immunofluorescence Microscopy of DNA Damage Response Biomarkers -- The Alkaline Comet Assay for Assessment of DNA Damage -- Application of the Comet Assay in Advanced In Vitro Models -- The Comet Assay in Human Biomonitoring -- The Comet Assay in Nano-Ecogenotoxicology -- Micronucleus Assay with Tetrad Cells of Tradescantia -- Application of Allium cepa Test for Genetic Toxicology -- Methods to Study DNA Damage Using Drosophila melanogaster -- The Wing-Spot and the Comet Tests as Useful Assays Detecting Genotoxicity in Drosophila -- Organoids for Genotoxicity Assessment -- Modern Approaches in Genetic Toxicology Research: Insights from Next-Generation-Based RNA Sequencing -- Methods to Quantify the MicroRNA and Study Their Role in Genotoxic Stress -- In Silico Approaches in Predictive Genetic Toxicology -- Artificial Intelligence and Machine Learning-Based Approaches for Genetic Damage Prediction.
520 _aThis third edition volume explores the latest advancements in genotoxicity testing and combines established assays with emerging technologies. Organized into five thematic sections, the book examines gene mutation assays, assays for chromosomal abnormalities, tests for primary DNA damage, assays in alternatives to animal models, as well as multipronged approaches to the assessment of genotoxicity. Written for the highly successful Methods in Molecular Biology series, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips for troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Genotoxicity Assessment: Methods and Protocols, Third Edition serves as a comprehensive resource for toxicologists, regulatory scientists, academicians, and students, dedicated to ensuring chemical safety in an evolving landscape of technological and scientific innovation.
532 8 _aAccessibility summary: This PDF has been created in accordance with the PDF/UA-1 standard to enhance accessibility, including screen reader support, described non-text content (images, graphs), bookmarks for easy navigation, keyboard-friendly links and forms and searchable, selectable text. We recognize the importance of accessibility, and we welcome queries about accessibility for any of our products. If you have a question or an access need, please get in touch with us at accessibilitysupport@springernature.com. Please note that a more accessible version of this eBook is available as ePub.
532 8 _aNo reading system accessibility options actively disabled
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650 0 _aToxicology.
650 0 _aGenetics.
650 1 4 _aToxicology.
650 2 4 _aGenetics.
700 1 _aDhawan, Alok.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
700 1 _aBajpayee, Mahima.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781071649756
776 0 8 _iPrinted edition:
_z9781071649770
776 0 8 _iPrinted edition:
_z9781071649787
830 0 _aMethods in Molecular Biology,
_x1940-6029 ;
_v2986
856 4 0 _uhttps://doi.org/10.1007/978-1-0716-4976-3
912 _aZDB-2-PRO
999 _c5270
_d5270