000 03834nam a22005055i 4500
001 978-1-4939-8922-5
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008 181211s2019 xxu| s |||| 0|eng d
020 _a9781493989225
_9978-1-4939-8922-5
024 7 _a10.1007/978-1-4939-8922-5
_2doi
050 4 _aRB155-155.8
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
072 7 _aMFN
_2thema
082 0 4 _a616.042
_223
245 1 0 _aSuicide Gene Therapy
_h[electronic resource] :
_bMethods and Protocols /
_cedited by Nejat Düzgüneş.
250 _a1st ed. 2019.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Humana,
_c2019.
300 _aXII, 190 p. 37 illus., 26 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aMethods in Molecular Biology,
_x1940-6029 ;
_v1895
505 0 _aOrigins of Suicide Gene Therapy -- Cancer Suicide Gene Therapy with TK.007 -- Osteonectin Promoter-Mediated Suicide Gene Therapy of Prostate Cancer -- Suicide Gene Therapy for Oral Squamous Cell Carcinoma -- Generation of Suicide Gene-Modified Chimeric Antigen Receptor-Redirected T-Cells for Cancer Immunotherapy -- Mesenchymal Stem Cell Exosome-Mediated Prodrug Gene Therapy for Cancer -- Extracellular Vesicles as Carriers of Suicide mRNA and/or Protein in Cancer Therapy -- Production of Viral Vectors with Suicide Genes by Utilizing the Intron-Splicing Mechanism of Insect Cells -- Resveratrol-Responsive CArG Elements from the Egr-1 Promoter for the Induction of GADD45α to Arrest the G2/M Transition -- Non-Invasive Monitoring of Suicide Gene Therapy by Using Multimodal Molecular Imaging -- In Vitro Assay for the Evaluation of Cytotoxic Effects Provided by a Combination of Suicide and Killer Genes in a Bicistronic Vector -- Engineered Thymidine-Active Deoxycytidine Kinase for Bystander Killing of Malignant Cells -- Photochemical Internalization Enhanced Non-Viral Suicide Gene Therapy -- Suicide Gene Therapy of Oral Squamous Cell Carcinoma and Cervical Carcinoma In Vitro.
520 _aThis detailed volume explores the methods used for most of the recent approaches to suicide gene therapy of cancer, which exploits promoters that are specific to cancer cells, thereby ensuring (or greatly increasing the likelihood) that the therapeutic gene is expressed only in cancer cells. The book also contains chapters describing methods to improve the safety of cell therapy and techniques utilizing bone marrow mesenchymal cells. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Suicide Gene Therapy: Methods and Protocols serves as an ideal guide for researchers expanding upon our knowledge and application of this vital form of cancer therapy.
650 0 _aMedical genetics.
650 0 _aCancer.
650 0 _aMedicine
_xResearch.
650 0 _aBiology
_xResearch.
650 1 4 _aClinical Genetics.
650 2 4 _aCancer Biology.
650 2 4 _aBiomedical Research.
700 1 _aDüzgüneş, Nejat.
_eeditor.
_4edt
_4http://id.loc.gov/vocabulary/relators/edt
710 2 _aSpringerLink (Online service)
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9781493989218
776 0 8 _iPrinted edition:
_z9781493989232
830 0 _aMethods in Molecular Biology,
_x1940-6029 ;
_v1895
856 4 0 _uhttps://doi.org/10.1007/978-1-4939-8922-5
912 _aZDB-2-PRO
999 _c5205
_d5205