TY  - BOOK
AU  - Paglia,Giuseppe
AU  - Astarita,Giuseppe
ED  - SpringerLink (Online service)
TI  - Ion Mobility-Mass Spectrometry: Methods and Protocols 
T2  - Methods in Molecular Biology,
SN  - 9781071600306
AV  - QD415-436 
U1  - 572 23
PY  - 2020///
CY  - New York, NY
PB  - Springer US, Imprint: Humana
KW  - Biochemistry
KW  - Mass spectroscopy
KW  - Mass Spectrometry
N1  - Fundamentals of Ion Mobility-Mass Spectrometry for the Analysis of Biomolecules -- Utilizing Drift Tube Ion Mobility Spectrometry for the Evaluation of Metabolites and Xenobiotics -- Untargeted Differential Metabolomics Analysis Using Drift Tube Ion Mobility-Mass Spectrometry -- Drift Tube Ion Mobility-Mass Spectrometry for Non-Targeted 'Omics -- The Use of DMS-MS for the Quantitative Analysis of Acylcarnitines -- Traveling Wave Ion Mobility-Mass Spectrometry to Enhance the Detection of Low Abundance Features in Untargeted Lipidomics -- Lipidomics by HILIC-Ion Mobility-Mass Spectrometry -- A Workflow for the Identification of Mycotoxin Metabolites Using Liquid Chromatography–Ion Mobility-Mass Spectrometry -- Quantitation of Cyclosporin A in Cell Culture Media by Differential Mobility Mass Spectrometry (DMS-MS/MS) -- An Analytical Perspective on Protein Analysis and Discovery Proteomics by Ion Mobility-Mass Spectrometry -- Ion Mobility-Mass Spectrometry to Evaluate the Effects of Protein Modification or Small Molecule Binding on Protein Dynamics -- Liquid Extraction Surface Analysis (LESA) High Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) Mass Spectrometry for In Situ Analysis of Intact Proteins -- Ion Mobility-Mass Spectrometry of Glycoconjugates -- Desorption Atmospheric Pressure Photoionization Coupled with Ion Mobility-Mass Spectrometry -- Metabolomic Profiling of Adherent Mammalian Cells In Situ by LAESI-MS with Ion Mobility Separation -- Matrix-Assisted Laser Desorption and Desorption Electrospray Ionization Mass Spectrometry Coupled to Ion Mobility -- The Use of LipidIMMS Analyzer for Lipid Identification in Ion Mobility-Mass Spectrometry-Based Untargeted Lipidomics -- MolFind2: A Protocol for Acquiring and Integrating MS3 Data to Improve In-Silico Chemical Structure Elucidation for Metabolomics -- Collision Cross Section Calculations Using HPCCS
N2  - This book focuses on ion mobility-mass spectrometry (IM-MS) and informatics approaches to improve traditional analysis of molecules by providing fundamentals and protocols for exploiting the potential of state-of-the-art IM-MS technology for the most common analytical applications. The chapters have been organized into four parts, each dealing with a particular set of IM-MS applications: 1) metabolomics and lipidomics; 2) proteomics and glycomics; 3) imaging and ambient ionization IM-MS; and 4) bioinformatic solutions for analyzing IM-MS data and deriving CCS values. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Ion Mobility-Mass Spectrometry: Methods and Protocols serves as anideal resource for scientists delving into the technique's unprecedented analytical advantages, enabling novel qualitative and quantitative applications for the analysis of complex biological samples
UR  - https://doi.org/10.1007/978-1-0716-0030-6
ER  -