A Novel Method to Estimate Levels of Receptors Using an Allosteric Modulator. Focus on muscarinic M1 receptors -- Enhanced bystander BRET (ebBRET) biosensors as biophysical tools to map the signaling profile of neuropsychiatric drugs targeting GPCR -- [35S]GTPγS (Guanosine-5′-O-(γ-thio)triphosphate-[35S]) Binding Scintillation Proximity Assay experiments in postmortem brain tissue -- CRISPR/Cas9 as a simple technique for the generation of murine knockout models for neuropsychiatric diseasesEvaluation of sensory-motor gating deficits in mice th -- rough prepulse inhibition (PPI) of the startle response -- Automated detection of psychedelic-induced head twitch response in mice -- Gastrointestinal and microbiome profiling in rodent models of neurological and psychiatric disorders -- Electroencephalography for the study of the auditory P300 evoked potential and derived measurements -- Quantification of endocannabinoids in human plasma -- Neuropsychological and functional assessment of cognitive impairments in schizophrenia -- Clinical management and assessment of the early stages of psychosis: a multidimensional approach.

This volumes presents current methods used in the research of schizophrenia. Chapters guide readers through molecular techniques, in vivo approaches, cell cultures and heterologous expression systems, and even research methods involving human studies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Schizophrenia: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.

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