npj Structural Biology considers research that leverages structure, dynamics and interactions of biological macromolecules at atomic and molecular resolution to understand essential biological functions and events. We are also interested in how structure underpins disease mechanisms and how it enables the generation novel tools and regulators to understand function and disease. The journal covers a broad range of topics, including but not limited to: Role of structure in biological function and disease Protein folding, dynamics and conformational changes in biological function and disease DNA, RNA and nucleic acid-protein interactions Macromolecular complex structure Membrane protein structure Post-translational modifications affecting structure and biological function In silico structure prediction and molecular simulations Large scale AlphaFold studies Protein design Structure-based tool/drug discovery Advances in relevant technologies and analysis, including AI Methodological advances: sample preparation, data processing, standards of reporting.