Cell Signaling, Inflammation and Disease (CSID) is an open-access, peer-reviewed journal dedicated to publishing high-quality research on the molecular and cellular signaling pathways that initiate, sustain, or resolve inflammation, drive chronic disease, and govern context-specific cell death. As a partner journal to Cell Communication and Signaling, CSID emphasizes translational and disease-focused studies that deepen our understanding of pathological signaling and inform therapeutic innovation. CSID also welcomes fundamental mechanistic studies that elucidate signaling principles in physiological and developmental contexts. The journal publishes original research articles, reviews, short reports, and commentaries across a wide range of interdisciplinary topics, including but not limited to: Dysregulated signaling pathways in chronic inflammatory and degenerative diseases Crosstalk between immune, metabolic, and tissue-specific pathways Programmed cell-death modalities linked to inflammation (e.g., pyroptosis, ferroptosis, necroptosis) Inflammatory signaling in cancer, neurodegeneration, cardiovascular, and metabolic disorders Biomarker discovery and therapeutic targeting of signaling nodes Systems biology, multi-omics, and high-throughput approaches Microbiome-host interactions and immunometabolism Physiological signaling studies that provide insight into inflammation-related mechanisms Translational models, preclinical validation, and early clinical studies CSID aims to serve as a platform for impactful research that bridges basic science and clinical application, addressing the urgent need for new insights and further research in inflammation-driven diseases.