Broadly speaking, the Journal of Pharmacokinetics and Pharmacodynamics covers all areas of pharmacometrics and related disciplines, which includes (population) pharmacokinetics-pharmacodynamics, physiological-based pharmacokinetics (PBPK), systems pharmacology (QSP), and application of machine learning to pharmacokinetics-pharmacodynamics. The journal is devoted to all aspects of pharmacokinetics, pharmacodynamics, and the application of pharmacometrics to drug development and clinical care. The journal publishes on all topics related to pharmacometrics, including, but not limited to, clinical, experimental, and theoretical papers examining the kinetics of drug disposition and effects of drug action; modeling and simulation methodology; PBPK; QSP; precision medicine; and mathematical pharmacology (including computational biology, bioengineering, and biophysics related to pharmacology, pharmacokinetics, or pharmacodynamics). The journal does not strictly publish theoretical manuscripts. Clinical papers that include population pharmacokinetic-pharmacodynamic relationships are welcome, as are population pharmacokinetic papers of novel drugs or analyses with original methodology (without exposure-response analyses). The journal actively invites and promotes up-and-coming areas of pharmacometric research, such as real-world evidence and quality of life analyses. Journal of Pharmacokinetics and Pharmacodynamics publishes six issues a year.