The official journal of the International Structural Genomics Organization (ISGO) provides a peer-reviewed forum for the exchange and discussion of new data in structural and functional genomics. The scope includes: -          Determination of the three-dimensional structures of gene products including those with unknown biological functions -          Structure determination methodologies spanning X-ray crystallography, cryoEM, NMR spectroscopy, mass spectrometry, molecular modeling, and hybrid methods  -          Research and new methodologies for selection of molecules for study and sample production -          Experimental and structure-based functional analysis, data base design, and data mining -          Discussion of results of structural and functional genomics projects The Journal of Structural and Functional Genomics presents scientific articles in the following categories: original research articles, reviews, short structure notes, new software application notes and functional characterization notes.