Toll-Like Receptors (Record no. 8272)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05215nam a22005055i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-1-59745-541-1 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260610083718.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 100301s2009 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781597455411 |
| -- | 978-1-59745-541-1 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-1-59745-541-1 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QR180-189.5 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MJCM |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED044000 |
| Source | bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MJCM |
| Source | thema |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 571.96 |
| Edition information | 23 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.079 |
| Edition information | 23 |
| 245 10 - TITLE STATEMENT | |
| Title | Toll-Like Receptors |
| Medium | [electronic resource] : |
| Remainder of title | Methods and Protocols / |
| Statement of responsibility, etc. | edited by Claire E. McCoy, Luke A.J. O'Neill. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 1st ed. 2009. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Totowa, NJ : |
| Name of producer, publisher, distributor, manufacturer | Humana Press : |
| -- | Imprint: Humana, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2009. |
| 300 ## - online resource | |
| Extent | XXIV, 376 p. 71 illus., 5 illus. in color. |
| Other physical details | online resource. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS | |
| File type | text file |
| Encoding format | |
| Source | rda |
| 490 1# - SERIES STATEMENT | |
| Series statement | Methods in Molecular Biology, |
| International Standard Serial Number | 1940-6029 ; |
| Volume/sequential designation | 517 |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Methods to Detect and Analyze Toll-Like Receptors -- Expression Analysis of the Toll-Like Receptors in Human Peripheral Blood Mononuclear Cells -- Ligands, Cell-Based Models, and Readouts Required for Toll-Like Receptor Action -- Toll-Like Receptor Interactions Imaged by FRET Microscopy and GFP Fragment Reconstitution -- Predicting Toll-Like Receptor Structures and Characterizing Ligand Binding -- Bioinformatic Analysis of Toll-Like Receptor Sequences and Structures -- Expression, Purification, and Crystallization of Toll/Interleukin-1 Receptor (TIR) Domains -- Methods to Analyze Signal Transduction Downstream of Toll-Like Receptor Stimulation -- Proteomic Analysis of Protein Complexes in Toll-Like Receptor Biology -- 2D-DIGE: Comparative Proteomics of Cellular Signalling Pathways -- MAPPIT (Mammalian Protein–Protein Interaction Trap) Analysis of Early Steps in Toll-Like Receptor Signalling -- Analysis of the Functional Role of Toll-Like Receptor-4 Tyrosine Phosphorylation -- Analysis of Ubiquitin Degradation and Phosphorylation of Proteins -- The Generation of Highly Purified Primary Human Neutrophils and Assessment of Apoptosis in Response to Toll-Like Receptor Ligands -- Cellular Expression of A20 and ABIN-3 in Response to Toll-Like Receptor-4 Stimulation -- Characterisation of Viral Proteins that Inhibit Toll-Like Receptor Signal Transduction -- Genetic Techniques in Toll-Like Receptor Analysis -- Genetic Dissection of Toll-Like Receptor Signaling Using ENU Mutagenesis -- Microarray Experiments to Uncover Toll-Like Receptor Function -- Uncovering Novel Gene Function in Toll-Like Receptor Signalling Using siRNA -- Genotyping Methods to Analyse Polymorphisms in Toll-Like Receptors and Disease -- Toll-Like Receptors and Disease -- Experimental Models of Acute Infection and Toll-LikeReceptor Driven Septic Shock -- Toll-Like Receptors and Rheumatoid Arthritis -- Practical Techniques for Detection of Toll-Like Receptor-4 in the Human Intestine -- Toll-Like Receptor-Dependent Immune Complex Activation of B Cells and Dendritic Cells -- Innate Immunity, Toll-Like Receptors, and Atherosclerosis: Mouse Models and Methods -- Generation of Parasite Antigens for Use in Toll-Like Receptor Research -- Biomarkers Measuring the Activity of Toll-Like Receptor Ligands in Clinical Development Programs. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In addition to their invaluable role in the fight against infection, Toll-Like Receptors (TLRs) in an under- or over-active state can lead to the pathogenesis of disease, making these receptors a key focal point for many research laboratories. In Toll-Like Receptors: Methods and Protocols, experts in the field contribute techniques currently used to study TLRs, their downstream signalling pathways, and their role in the pathogenesis of disease, with sections examining TLR expression and the application of genetic techniques and microarray analysis to TLR research. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to the topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and Notes sections highlighting tips on troubleshooting and avoiding known pitfalls. Versatile and cutting-edge, Toll-Like Receptors: Methods and Protocols provides an ideal manual for a wide range of biologists and medical researchers studying these vital components of the immune system. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Immunology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cytokines. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Immunology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cytokines and Growth Factors. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | McCoy, Claire E. |
| Relator term | editor. |
| Relationship | edt |
| -- | http://id.loc.gov/vocabulary/relators/edt |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | O'Neill, Luke A.J. |
| Relator term | editor. |
| Relationship | edt |
| -- | http://id.loc.gov/vocabulary/relators/edt |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer Nature eBook |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9781934115725 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9781603275910 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9781617379420 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Methods in Molecular Biology, |
| International Standard Serial Number | 1940-6029 ; |
| Volume/sequential designation | 517 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1007/978-1-59745-541-1">https://doi.org/10.1007/978-1-59745-541-1</a> |
| 912 ## - | |
| -- | ZDB-2-PRO |
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