Antibody Engineering Volume 2 (Record no. 8183)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05006nam a22005055i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-3-642-01147-4 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260610083716.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 100308s2010 gw | s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783642011474 |
| -- | 978-3-642-01147-4 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-3-642-01147-4 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QR180-189.5 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MJCM |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED044000 |
| Source | bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MJCM |
| Source | thema |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 571.96 |
| Edition information | 23 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.079 |
| Edition information | 23 |
| 245 10 - TITLE STATEMENT | |
| Title | Antibody Engineering Volume 2 |
| Medium | [electronic resource] / |
| Statement of responsibility, etc. | edited by Roland E. Kontermann, Stefan Dübel. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 2nd ed. 2010. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Berlin, Heidelberg : |
| Name of producer, publisher, distributor, manufacturer | Springer Berlin Heidelberg : |
| -- | Imprint: Springer, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2010. |
| 300 ## - online resource | |
| Extent | XII, 589 p. |
| Other physical details | online resource. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS | |
| File type | text file |
| Encoding format | |
| Source | rda |
| 490 1# - SERIES STATEMENT | |
| Series statement | Springer Protocols Handbooks, |
| International Standard Serial Number | 1949-2456 |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Bioinformatics of Antigen-binding Sites -- Analysis of Single Chain Antibody Sequences Using the VBASE2 Fab Analysis Tool -- Standardized Sequence and Structure Analysis of Antibody Using IMGT® -- Protein Sequence and Structure Analysis of Antibody Variable Domains -- Generation of Antibody Fragments and Their Derivatives -- scFv by Two-Step Cloning -- Bivalent Diabodies -- Generation of Single-Chain Fv Fragments and Multivalent Derivatives scFv-Fc and scFv-CH3 (Minibodies) -- Miniantibodies -- Generation of Stably Transfected Eukaryotic Cell Lines Producing ImmunoRNAse Fusion Proteins -- Antibody–Cytokine Fusion Proteins with Members of the TNF-Family -- Recombinant Immunotoxins for Treating Cancer -- T Bodies -- Expressing Intrabodies in Mammalian Cells -- Phenotypic Knockdown with Intrabodies -- Disulfide-Stabilized Fv Fragments -- PEGylation of Antibody Fragments to Improve Pharmacodynamics and Pharmacokinetics -- Fusion Proteins with Improved PK -- In Vivo Biotinylated scFv Fragments -- Bispecific Diabodies and Single-Chain Diabodies -- Generation and Characterization of a Dual Variable Domain Immunoglobulin (DVD-Ig™) Molecule -- Isolation of Antigen-Specific Nanobodies -- CDR-FR Peptides -- Production of Antibody Fragments -- Purification and Characterization of His-Tagged Antibody Fragments -- Production of Antibody Fragments in the Gram-Positive Bacterium Bacillus megaterium -- Analysis and Purification of Antibody Fragments Using Protein A, Protein G, and Protein L -- Purification and Analysis of Strep-tagged Antibody-Fragments -- Production of Antibodies and Antibody Fragments in Escherichia coli -- Improving Expression of scFv Fragments by Co-expression of Periplasmic Chaperones -- Bioreactor Production of scFv Fragments in Pichia pastoris -- Expression of Antibody Fragments in Transgenic Plants -- Transient Production of scFv-Fc Fusion Proteins in Mammalian Cells -- Recombinant Antibody Molecules in Nanobiotechnology and Proteomics -- Immunoliposomes -- Targeted Polymeric Nanoparticles.-Antibody Microarrays for Expression Analysis -- Evaluation of Recombinant Antibodies on Protein Microarrays Applying the Multiple Spotting Technique -- Preclinical and Clinical Development -- Xenograft Mouse Models for Tumour Targeting -- Xenograft Mouse Models for Tumour Targeting -- Imaging Tumor Xenografts Using Radiolabeled Antibodies -- Human Anti-antibody Response -- IP Issues in the Therapeutic Antibody Industry. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. Antibody Engineering provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Immunology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Immunospecificity. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Immunology. |
| 650 24 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Adaptive Immunity. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kontermann, Roland E. |
| Relator term | editor. |
| Relationship | edt |
| -- | http://id.loc.gov/vocabulary/relators/edt |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dübel, Stefan. |
| Relator term | editor. |
| Relationship | edt |
| -- | http://id.loc.gov/vocabulary/relators/edt |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer Nature eBook |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9783642011467 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9783642011481 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9783642422768 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Springer Protocols Handbooks, |
| International Standard Serial Number | 1949-2456 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1007/978-3-642-01147-4">https://doi.org/10.1007/978-3-642-01147-4</a> |
| 912 ## - | |
| -- | ZDB-2-PRO |
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