Cytotoxic Drug Resistance Mechanisms (Record no. 7723)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03722nam a22004695i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-1-59259-687-4 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260610083708.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 100301s1999 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781592596874 |
| -- | 978-1-59259-687-4 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1385/1592596878 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RC254-282 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MJCL |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED062000 |
| Source | bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MJCL |
| Source | thema |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.994 |
| Edition information | 23 |
| 245 10 - TITLE STATEMENT | |
| Title | Cytotoxic Drug Resistance Mechanisms |
| Medium | [electronic resource] / |
| Statement of responsibility, etc. | edited by Robert Brown, Uta Böger-Brown. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 1st ed. 1999. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | Totowa, NJ : |
| Name of producer, publisher, distributor, manufacturer | Humana Press : |
| -- | Imprint: Humana, |
| Date of production, publication, distribution, manufacture, or copyright notice | 1999. |
| 300 ## - online resource | |
| Extent | XI, 238 p. |
| Other physical details | online resource. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS | |
| File type | text file |
| Encoding format | |
| Source | rda |
| 490 1# - SERIES STATEMENT | |
| Series statement | Methods in Molecular Medicine, |
| International Standard Serial Number | 1940-6037 ; |
| Volume/sequential designation | 28 |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Drug Resistance -- Cell Sensitivity Assays -- Cell Sensitivity Assays -- Cell Sensitivity Assays -- Analysis of Apoptosis in Tissue Sections -- Measurement of P-glycoprotein Function -- Measuring MDR-1 by Quantitative RT-PCR -- Microtiter Plate Technique for the Measurement of Glutathione in Fresh and Cryopreserved Lymphoblasts Using the Enzyme Recycling Method -- Measurement of Reduced Glutathione Using High-Pressure Liquid Chromatography -- Topoisomerase I and II Activity Assays -- 5-Fluorouracil Metabolizing Enzymes -- Measuring DNA Adducts by Immunoassay (ELISA) -- Measuring Drug-DNA Adducts in Individual Cells -- Measurement of Drug-Induced DNA Interstrand Crosslinking Using the Single-Cell Gel Electrophoresis (Comet) Assay -- PCR Analysis of Microsatellite Instability -- O 6-Alkylguanine-DNA Alkyltransferase Assay -- Analysis of the p53 Status of Tumors -- Bcl-2 Family Immunohistochemistry -- Genetic Analysis of Drug Resistance by Fluorescence In Situ Hybridization -- Genetic Analysis of Drug Resistance by Reverse In Situ Hybridization. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In Cytotoxic Drug Resistance Mechanisms, leading clinical and laboratory scientists describe cutting-edge methods for examining the mechanisms of cellular resistance to anticancer cytotoxics in human tumors. The protocols contain detailed instructions and extensive troubleshooting tips that allow researchers effectively to study a wide variety of drug resistance mechanisms, including aspects of drug-induced cell death, drug uptake/efflux, drug metabolism, and DNA repair. Each method is designed to help identify the correlation between molecular and biochemical data and the clinical responses of the patient. Cytotoxic Drug Resistance Mechanisms makes it possible to test established and laboratory-derived hypotheses with clinically derived tumor samples. State-of-the-art and readily reproducible, the methods presented here afford basic and clinical scientists a powerful complement of tools for investigating all the clinically relevant mechanisms used as markers of the biological response to anticancer chemotherapeutics today. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Oncology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Oncology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Brown, Robert. |
| Relator term | editor. |
| Relationship | edt |
| -- | http://id.loc.gov/vocabulary/relators/edt |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Böger-Brown, Uta. |
| Relator term | editor. |
| Relationship | edt |
| -- | http://id.loc.gov/vocabulary/relators/edt |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer Nature eBook |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9780896036031 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9781617370939 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9781489941725 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Methods in Molecular Medicine, |
| International Standard Serial Number | 1940-6037 ; |
| Volume/sequential designation | 28 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1385/1592596878">https://doi.org/10.1385/1592596878</a> |
| 912 ## - | |
| -- | ZDB-2-PRO |
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