Alpha-1 Antitrypsin Deficiency (Record no. 6823)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04755nam a22004935i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-1-4939-7163-3 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260610083653.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 170727s2017 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781493971633 |
| -- | 978-1-4939-7163-3 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-1-4939-7163-3 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | R850.A1-854 |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | QH315-320 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MBGR |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED106000 |
| Source | bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MBGR |
| Source | thema |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 610.72 |
| Edition information | 23 |
| 245 10 - TITLE STATEMENT | |
| Title | Alpha-1 Antitrypsin Deficiency |
| Medium | [electronic resource] : |
| Remainder of title | Methods and Protocols / |
| Statement of responsibility, etc. | edited by Florie Borel, Christian Mueller. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 1st ed. 2017. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | New York, NY : |
| Name of producer, publisher, distributor, manufacturer | Springer New York : |
| -- | Imprint: Humana, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2017. |
| 300 ## - online resource | |
| Extent | XIII, 278 p. 71 illus., 42 illus. in color. |
| Other physical details | online resource. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS | |
| File type | text file |
| Encoding format | |
| Source | rda |
| 490 1# - SERIES STATEMENT | |
| Series statement | Methods in Molecular Biology, |
| International Standard Serial Number | 1940-6029 ; |
| Volume/sequential designation | 1639 |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Pathophysiology of Alpha-1 Antitrypsin Deficiency Liver Disease -- Pathophysiology of Alpha-1 Antitrypsin Lung Disease -- Measuring and Interpreting Serum AAT Concentration -- AAT Phenotype Identification by Isoelectric Focusing -- Laboratory Diagnosis by Genotyping -- Genotyping Protocol for the Alpha-1 Antitrypsin (PiZ) Mouse Model -- Elastase-Induced Lung Emphysema Models in Mice -- Assessing Structure-Function Relations in Mice Using the Forced Oscillation Technique and Quantitative Histology -- Practical Methods for Assessing Emphysema Severity Based on Estimation of Linear Mean Intercept (Lm) in the Context of Animal Models of Alpha-1 Antitrypsin Deficiency -- Design, Cloning, and In Vitro Screening of Artificial miRNAs to Silence Alpha-1-Antitrypsin -- Methods to Identify and Characterize siRNAs Targeting Serpin A1 In Vitro and In Vivo using RNA Interference -- Knockdown of Z Mutant Alpha-1 Antitrypsin in Vivo Using Modified DNA Antisense Oligonucleotides -- Immunohistochemistry Staining for Human Alpha-1 Antitrypsin -- Periodic Acid-Schiff Staining with Diastase -- Protocol for Directed Differentiation of Human Induced Pluripotent Stem Cells (iPSCs) to a Hepatic Lineage -- Isolation of Kupffer Cells and Hepatocytes from a Single Mouse Liver -- Alpha-1 Antitrypsin Transcytosis and Secretion -- Measuring the Effect of Histone Deacetylase Inhibitors (HDACi) on the Secretion and Activity of Alpha-1 Antitrypsin -- Expression and Purification of Active Recombinant Human 1-Antitrypsin (AAT) from Escherichia coli -- Quantification of Total Human Alpha-1 Antitrypsin by Sandwich ELISA -- Quantification of Murine AAT by Direct ELISA -- Quantification of Z-AAT by a Z-Specific “Sandwich” ELISA -- Semi-Quantitation of Monomer and Polymer Alpha-1 Antitrypsin by Centrifugal Separation and Assay by Western Blot of Soluble and Insoluble Components -- Electrophoresis- and FRET-Based Measures of Serpin Olymerization -- Therapeutics: Alpha-1 Antitrypsin Augmentation Therapy -- Therapeutic Option in Alpha-1 Antitrypsin Liver Transplantation -- Therapeutics: Gene Therapy for Alpha-1 Antitrypsin Deficiency. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This volume provides protocols that expand on the latest alpha-1 antitrypsin (AAT) research. The chapters in this book are divided in to three sections: Part I is dedicated to patient-oriented research; part II discusses animal models; and Part III focuses on in vitro studies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Alpha-1 Antitrypsin Deficiency: Methods and Protocols is a valuable resource for researchers, students, and clinican-scientists interested in AAT deficiency, as well as anyone working in the fields of pulmonology and hepatology. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Medicine |
| General subdivision | Research. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biology |
| General subdivision | Research. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Biomedical Research. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Borel, Florie. |
| Relator term | editor. |
| Relationship | edt |
| -- | http://id.loc.gov/vocabulary/relators/edt |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mueller, Christian. |
| Relator term | editor. |
| Relationship | edt |
| -- | http://id.loc.gov/vocabulary/relators/edt |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer Nature eBook |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9781493971619 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9781493971626 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9781493984039 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Methods in Molecular Biology, |
| International Standard Serial Number | 1940-6029 ; |
| Volume/sequential designation | 1639 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1007/978-1-4939-7163-3">https://doi.org/10.1007/978-1-4939-7163-3</a> |
| 912 ## - | |
| -- | ZDB-2-PRO |
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