Drug-Induced Liver Toxicity (Record no. 6762)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05537nam a22004695i 4500 |
| 001 - CONTROL NUMBER | |
| control field | 978-1-4939-7677-5 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | DE-He213 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260610083652.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION | |
| fixed length control field | cr nn 008mamaa |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 180321s2018 xxu| s |||| 0|eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9781493976775 |
| -- | 978-1-4939-7677-5 |
| 024 7# - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.1007/978-1-4939-7677-5 |
| Source of number or code | doi |
| 050 #4 - LIBRARY OF CONGRESS CALL NUMBER | |
| Classification number | RM300-666 |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MMG |
| Source | bicssc |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MED071000 |
| Source | bisacsh |
| 072 #7 - SUBJECT CATEGORY CODE | |
| Subject category code | MKG |
| Source | thema |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615 |
| Edition information | 23 |
| 245 10 - TITLE STATEMENT | |
| Title | Drug-Induced Liver Toxicity |
| Medium | [electronic resource] / |
| Statement of responsibility, etc. | edited by Minjun Chen, Yvonne Will. |
| 250 ## - EDITION STATEMENT | |
| Edition statement | 1st ed. 2018. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Place of production, publication, distribution, manufacture | New York, NY : |
| Name of producer, publisher, distributor, manufacturer | Springer New York : |
| -- | Imprint: Humana, |
| Date of production, publication, distribution, manufacture, or copyright notice | 2018. |
| 300 ## - online resource | |
| Extent | XX, 667 p. 119 illus., 70 illus. in color. |
| Other physical details | online resource. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Content type code | txt |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | computer |
| Media type code | c |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | online resource |
| Carrier type code | cr |
| Source | rdacarrier |
| 347 ## - DIGITAL FILE CHARACTERISTICS | |
| File type | text file |
| Encoding format | |
| Source | rda |
| 490 1# - SERIES STATEMENT | |
| Series statement | Methods in Pharmacology and Toxicology, |
| International Standard Serial Number | 1940-6053 |
| 505 0# - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Overview of Mechanisms of Drug-Induced Liver Injury (DILI) and Key Challenges in DILI Research -- Detection, Elimination, Mitigation, and Prediction of Drug-Induced Liver Injury in Drug Discovery -- Drug-Induced Liver Injury (DILI) Classification and Its Application on Human DILI Risk Prediction -- Physicochemical Properties and Structural Alerts -- Quantitative Structure-Activity Relationship Models for Predicting Risk of Drug-Induced Liver Injury in Humans -- An Introduction to DILIsym® Software, a Mechanistic Mathematical Representation of Drug-Induced Liver Injury -- Prediction of Human Liver Toxicity Using In Vitro Assays: Limitations and Opportunities -- Use of Liver-Derived Cell Lines for the Study of Drug-Induced Liver Injury -- Evaluation of Drug-induced Liver Injuries (DILI) with Human Hepatocytes: Scientific Rationale and Experimental Approaches -- Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testing -- Engineered Human Liver Co-Culturesfor Investigating Drug-Induced Liver Injury -- Status and Future of 3D Cell Culture in Toxicity Testing -- Reactive Metabolite Assessment in Drug Discovery and Development in Support of Safe Drug Design -- In Vitro Assessment of Mitochondrial Toxicity to Predict Drug-Induced Liver Injury -- Bile Salt Export Pump: Drug-Induced Liver Injury and Assessment Approaches -- High Content Screening for Prediction of Human Drug-Induced Liver Injury -- Interpretation, Integration, and Implementation of In Vitro Assay Data: The Predictive Toxicity Challenge -- Perspectives on the Regulatory and Clinical Science of Drug-Induced Liver Injury (DILI) -- Regulatory Toxicological Studies: Identifying Drug-Induced Liver Injury Using Nonclinical Studies -- Hy’s Law and eDISH for Clinical Studies -- Variability in Baseline Liver Test Values in Clinical Trials: Challenges in Enhancing Drug-Induced Liver Injury Assessment in Subjects with Liver Disease -- Postmarketing Surveillance of Drug-Induced Liver Injury -- HostRisk Modifiers in Idiosyncratic Drug-Induced Liver Injury (DILI) and Its Interplay with Drug Properties -- Human Leukocyte Antigen (HLA) and Other Genetic Risk Factors in Drug-Induced Liver Injury (DILI) -- Immune Mechanisms in Drug-Induced Liver Injury -- Translational and Mechanistic Biomarkers of Drug-Induced Liver Injury -- Causality Assessment Methods in Drug-Induced Liver Injury -- Circulating MicroRNAs as Novel Biomarkers of Drug-Induced Liver Injury in Humans -- Systems Microscopy Approaches in Unraveling and Predicting Drug-Induced Liver Injury (DILI) -- Non-Invasive Pre-Clinical and Clinical Imaging of Liver Transporter Function Relevant to Drug-Induced Liver Injury. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six sections, the first section introduces the mechanisms contributing to drug-induced liver toxicity. The second and third section explore in silico and in vitro approaches used to help mitigate hepatotoxicity liability at the early stages of drug development. The fourth section describes methodologies applied in regulatory processes, including preclinical studies, clinical trials, and post-marketing surveillance. The fifth section discusses clinical hepatotoxicity. Emerging technologies are examined in the final section. As a volume in the Methods in Pharmacology and Toxicology series, chapters include the kind of expert advice that will lead to optimal results. Authoritative and practical, Drug-Induced Liver Toxicity serves all those who aim to improve assessment and understanding of hepatotoxic potentials of new medications and marketed drugs. Chapter 30 is open access under a CC BY 4.0 license via link.springer.com. . |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pharmacology. |
| 650 14 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pharmacology. |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chen, Minjun. |
| Relator term | editor. |
| Relationship | edt |
| -- | http://id.loc.gov/vocabulary/relators/edt |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Will, Yvonne. |
| Relator term | editor. |
| Relationship | edt |
| -- | http://id.loc.gov/vocabulary/relators/edt |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | SpringerLink (Online service) |
| 773 0# - HOST ITEM ENTRY | |
| Title | Springer Nature eBook |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9781493976768 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9781493976782 |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY | |
| Relationship information | Printed edition: |
| International Standard Book Number | 9781493992560 |
| 830 #0 - SERIES ADDED ENTRY--UNIFORM TITLE | |
| Uniform title | Methods in Pharmacology and Toxicology, |
| International Standard Serial Number | 1940-6053 |
| 856 40 - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1007/978-1-4939-7677-5">https://doi.org/10.1007/978-1-4939-7677-5</a> |
| 912 ## - | |
| -- | ZDB-2-PRO |
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